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• W4382364637 endingPage "117457" @default.
• W4382364637 startingPage "117457" @default.
• W4382364637 abstract "We aimed to evaluate the diagnostic performance and prognostic value of disease-specific antibodies and anti-Ro52 using a commercial line immunoblot assay (LIA) in Taiwanese patients with systemic sclerosis (SSc). We retrospectively enrolled all individuals at the Taichung Veterans General Hospital. We evaluated the diagnostic performance of LIA, anti-nuclear antibody (ANA) by indirect immunofluorescence (IIF) and also the association between the autoantibodies and the clinical phenotype using multivariable logistic regression. The LIA exhibited a sensitivity of 65.4% and a specificity of 65.4%, at the optimal cutoff values of 2 + signal intensity. By taking the result of ANA into consideration, the optimal cutoff point was redefined as 1+. We observed a higher risk of diffuse cutaneous SSc (dcSSc) in those with negative autoantibodies, positive anti-Scl-70, anti-RNA polymerase III, and anti-Ro-52. Interstitial lung disease (ILD) was associated with negative autoantibodies, as well as positive anti-Scl-70 and anti-Ro52. Anti-Ro52 positivity was also associated with pulmonary arterial hypertension (PAH) and gastrointestinal tract involvement. The presence of anti-Ro52 or the absence of SSc-specific autoantibodies may potentially indicate advanced diseases in patients with SSc. The incorporation of both IIF and LIA testing may improve the diagnostic specificity of SSc." @default.
• W4382364637 created "2023-06-29" @default.
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• W4382364637 date "2023-07-01" @default.
• W4382364637 modified "2023-10-12" @default.
• W4382364637 title "The diagnostic and prognostic value of a line immunoblot assay in Taiwanese patients with systemic sclerosis" @default.
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• W4382364637 doi "https://doi.org/10.1016/j.cca.2023.117457" @default.
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• W4382364637 hasPublicationYear "2023" @default.
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