Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382364676> ?p ?o ?g. }
- W4382364676 endingPage "163" @default.
- W4382364676 startingPage "144" @default.
- W4382364676 abstract "GPR81 is a G-protein coupled receptor (GPCR) discovered in 2001, but deorphanized only 7 years later, when its affinity for lactate as an endogenous ligand was demonstrated. More recently, GPR81 expression and distribution in the brain were also confirmed and the function of lactate as a volume transmitter has been suggested since then. These findings shed light on a new function of lactate acting as a signaling molecule in the central nervous system, in addition to its well-known role as a metabolic fuel for neurons. GPR81 seems to act as a metabolic sensor, coupling energy metabolism, synaptic activity, and blood flow. Activation of this receptor leads to Gi-mediated downregulation of adenylyl cyclase and subsequent reduction in cAMP levels, regulating several downstream pathways. Recent studies have also suggested the potential role of lactate as a neuroprotective agent, mainly under brain ischemic conditions. This effect is usually attributed to the metabolic role of lactate, but the underlying mechanisms need further investigation and could be related to lactate signaling via GPR81. The activation of GPR81 showed promising results for neuroprotection: it modulates many processes involved in the pathophysiology of ischemia. In this review, we summarize the history of GPR81, starting with its deorphanization; then, we discuss GPR81 expression and distribution, signaling transduction cascades, and neuroprotective roles. Lastly, we propose GPR81 as a potential target for the treatment of cerebral ischemia." @default.
- W4382364676 created "2023-06-29" @default.
- W4382364676 creator A5006784286 @default.
- W4382364676 creator A5023473884 @default.
- W4382364676 creator A5054091454 @default.
- W4382364676 creator A5071054489 @default.
- W4382364676 date "2023-08-01" @default.
- W4382364676 modified "2023-10-17" @default.
- W4382364676 title "History and Function of the Lactate Receptor GPR81/HCAR1 in the Brain: A Putative Therapeutic Target for the Treatment of Cerebral Ischemia" @default.
- W4382364676 cites W1504280911 @default.
- W4382364676 cites W1512566308 @default.
- W4382364676 cites W1517339234 @default.
- W4382364676 cites W1551543102 @default.
- W4382364676 cites W1591803971 @default.
- W4382364676 cites W1603743029 @default.
- W4382364676 cites W1616394907 @default.
- W4382364676 cites W1774597541 @default.
- W4382364676 cites W1965004625 @default.
- W4382364676 cites W1966907215 @default.
- W4382364676 cites W1971082249 @default.
- W4382364676 cites W1971285535 @default.
- W4382364676 cites W1975182142 @default.
- W4382364676 cites W1976143339 @default.
- W4382364676 cites W1976762010 @default.
- W4382364676 cites W1980001999 @default.
- W4382364676 cites W1980243755 @default.
- W4382364676 cites W1980301450 @default.
- W4382364676 cites W1983146430 @default.
- W4382364676 cites W1985867562 @default.
- W4382364676 cites W1988714133 @default.
- W4382364676 cites W1991648436 @default.
- W4382364676 cites W1991928071 @default.
- W4382364676 cites W1998442807 @default.
- W4382364676 cites W1998976350 @default.
- W4382364676 cites W1999565511 @default.
- W4382364676 cites W2000501881 @default.
- W4382364676 cites W2001725826 @default.
- W4382364676 cites W2002869421 @default.
- W4382364676 cites W2004129180 @default.
- W4382364676 cites W2004679107 @default.
- W4382364676 cites W2006316800 @default.
- W4382364676 cites W2009966509 @default.
- W4382364676 cites W2016927879 @default.
- W4382364676 cites W2019260483 @default.
- W4382364676 cites W2019477006 @default.
- W4382364676 cites W2024515307 @default.
- W4382364676 cites W2026779231 @default.
- W4382364676 cites W2027079655 @default.
- W4382364676 cites W2029205073 @default.
- W4382364676 cites W2032507656 @default.
- W4382364676 cites W2034004233 @default.
- W4382364676 cites W2035421462 @default.
- W4382364676 cites W2035548856 @default.
- W4382364676 cites W2036732386 @default.
- W4382364676 cites W2038392123 @default.
- W4382364676 cites W2044463379 @default.
- W4382364676 cites W2046181551 @default.
- W4382364676 cites W2048424278 @default.
- W4382364676 cites W2050399087 @default.
- W4382364676 cites W2050442804 @default.
- W4382364676 cites W2052875832 @default.
- W4382364676 cites W2055493228 @default.
- W4382364676 cites W2055908419 @default.
- W4382364676 cites W2056934253 @default.
- W4382364676 cites W2056980398 @default.
- W4382364676 cites W2057966179 @default.
- W4382364676 cites W2059377502 @default.
- W4382364676 cites W2061537454 @default.
- W4382364676 cites W2063797549 @default.
- W4382364676 cites W2063932219 @default.
- W4382364676 cites W2064363886 @default.
- W4382364676 cites W2064380858 @default.
- W4382364676 cites W2064488696 @default.
- W4382364676 cites W2064539435 @default.
- W4382364676 cites W2064840258 @default.
- W4382364676 cites W2067635988 @default.
- W4382364676 cites W2067704925 @default.
- W4382364676 cites W2067898648 @default.
- W4382364676 cites W2070673067 @default.
- W4382364676 cites W2071719711 @default.
- W4382364676 cites W2071741407 @default.
- W4382364676 cites W2075164713 @default.
- W4382364676 cites W2079912123 @default.
- W4382364676 cites W2079933309 @default.
- W4382364676 cites W2079968925 @default.
- W4382364676 cites W2083907713 @default.
- W4382364676 cites W2084885101 @default.
- W4382364676 cites W2086554547 @default.
- W4382364676 cites W2090022476 @default.
- W4382364676 cites W2090369229 @default.
- W4382364676 cites W2090600090 @default.
- W4382364676 cites W2091715170 @default.
- W4382364676 cites W2092635505 @default.
- W4382364676 cites W2093111439 @default.
- W4382364676 cites W2093446988 @default.
- W4382364676 cites W2094217759 @default.
- W4382364676 cites W2094784513 @default.
- W4382364676 cites W2098685543 @default.