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- W4382364882 abstract "Gilbert´s syndrome, also known as benign hyperbilirubinemia, was described more than 100 years ago. It has usually been considered a physiological abnormality characterized by a mild elevation of the systemic level of unconjugated bilirubin, in the absence of any underlying liver or overt hemolytic disease. However, since the re-discovery of the potent antioxidant effects of bilirubin in the late 1980s, as well as multiple intracellular signaling pathways affected by bilirubin, an ever-increasing body of evidence suggests that subjects with Gilbert´s syndrome may benefit from the mild hyperbilirubinemia and are virtually protected from the development of a wide variety of “diseases of civilization” such as cardiovascular diseases, certain cancers, autoimmune or neurodegenerative diseases. This review analyzes the current state of medical knowledge given recent discoveries in this rapidly developing field, as well as their possible clinical significance, and gives a new perspective to this condition." @default.
- W4382364882 created "2023-06-29" @default.
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- W4382364882 date "2023-10-01" @default.
- W4382364882 modified "2023-10-03" @default.
- W4382364882 title "Gilbert’s syndrome revisited" @default.
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- W4382364882 doi "https://doi.org/10.1016/j.jhep.2023.06.004" @default.
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