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- W4382371087 abstract "Metastasis to the brain occurs in a significant fraction of patients with solid tumors including breast cancer and metastatic melanoma (1-3). We mined published and public RNA-sequencing and microarray data (4, 5), respectively, comparing primary and brain metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the CNS. We found that the NLR family and pyrin domain protein NLRP6 was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Study of public microarray data (5) revealed conserved differential expression of NLRP6 in CNS metastasis generated following xenograft of tumor cells from patients with melanoma. NLRP6 mRNA was present at decreased quantities in metastasis to the brain in humans with breast cancer. Expression of NLRP6 in primary tumors of the breast was correlated with patient overall and recurrence-free survival. Modulation of NLRP6 expression may be relevant to the biology by which tumor cells metastasize to the brain in humans with solid tumors with propensity for the CNS including breast cancer and metastatic melanoma." @default.
- W4382371087 created "2023-06-29" @default.
- W4382371087 creator A5024900493 @default.
- W4382371087 date "2023-06-28" @default.
- W4382371087 modified "2023-10-14" @default.
- W4382371087 title "NLRP6 is differentially expressed in central nervous system metastasis." @default.
- W4382371087 doi "https://doi.org/10.31219/osf.io/uk4z2" @default.
- W4382371087 hasPublicationYear "2023" @default.
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