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- W4382393592 endingPage "103717" @default.
- W4382393592 startingPage "103717" @default.
- W4382393592 abstract "Worldwide, hepatocellular carcinoma (HCC) is considered the sixth most prevalent cancer and ranked third in causes leading to death. Pterostilbene (PTE), a dimethylated analog of resveratrol, is a phytochemical found in fruits such as blueberries and grapes, and is known for its anticancer effect. The current study intended to investigate the effect of PTE on HepG2 cells. Cell viability, colony-forming potential, lipid peroxidation, catalase enzyme (CAT), superoxide dismutase (SOD), and caspase 3 activities, histone release, and expression levels of mTOR, S6K1, p53, and STAT3 proteins were assessed in PTE-treated HepG2 cells. In addition, the cellular and ultrastructural alterations were evaluated by light and transmission electron microscopy. PTE induced a significant reduction in HepG2 viability in a dose-dependent manner (IC50 of PTE = 74 ± 6 μM), accompanied by a decrease in colony formation potential. PTE-treated cancer cells exhibited a decrease in lipid peroxidation and CAT activity, and an increase in histone release, caspase-3, and SOD activities. Ultrastructurally, PTE-treated cells exhibited notable cell shrinkage, reduced number of filopodia, increased vacuolization, apoptotic bodies, accumulation of lipid droplets, enlarged mitochondria, dilated endoplasmic reticulum, pyknotic nuclei, and cellular fragmentation. mTOR, S6K1, and STAT3 levels were downregulated, however p53 level was modulated in PTE-treated cells. The anticancer potential of PTE might be related to its ability to alter the ultrastructure morphology, reduce mitotic activity, and modulate some key protein required for cell proliferation, suggesting its potential to trigger cancer cells towards apoptosis." @default.
- W4382393592 created "2023-06-29" @default.
- W4382393592 creator A5016574027 @default.
- W4382393592 creator A5022416083 @default.
- W4382393592 creator A5059129599 @default.
- W4382393592 creator A5076521107 @default.
- W4382393592 creator A5092349980 @default.
- W4382393592 date "2023-08-01" @default.
- W4382393592 modified "2023-09-26" @default.
- W4382393592 title "Pterostilbene induces apoptosis in hepatocellular carcinoma cells: Biochemical, pathological, and molecular markers" @default.
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- W4382393592 doi "https://doi.org/10.1016/j.sjbs.2023.103717" @default.
- W4382393592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37483838" @default.
- W4382393592 hasPublicationYear "2023" @default.