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- W4382397382 abstract "Plant nucleotide-binding and leucine-rich repeat (NLR) proteins are immune sensors that detect pathogen effectors and initiate a strong immune response. In many cases, single NLR proteins are sufficient for both effector recognition and signaling activation. These proteins possess a conserved architecture, including a C-terminal leucine-rich repeat (LRR) domain, a central nucleotide-binding (NB) domain, and a variable N-terminal domain. Nevertheless, many paired NLRs linked in a head-to-head configuration have now been identified. The ones carrying integrated domains (IDs) can recognize pathogen effector proteins by various modes; these are known as sensor NLR (sNLR) proteins. Structural and biochemical studies have provided insights into the molecular basis of heavy metal-associated IDs (HMA IDs) from paired NLRs in rice and revealed the co-evolution between pathogens and hosts by combining naturally occurring favorable interactions across diverse interfaces. Focusing on structural and molecular models, here we highlight advances in structure-guided engineering to expand and enhance the response profile of paired NLR-HMA IDs in rice to variants of the rice blast pathogen MAX-effectors ( Magnaporthe oryzae AVRs and ToxB-like). These results demonstrate that the HMA IDs-based design of rice materials with broad and enhanced resistance profiles possesses great application potential but also face considerable challenges." @default.
- W4382397382 created "2023-06-29" @default.
- W4382397382 creator A5001167337 @default.
- W4382397382 creator A5011448964 @default.
- W4382397382 creator A5014020226 @default.
- W4382397382 creator A5016280362 @default.
- W4382397382 creator A5040846880 @default.
- W4382397382 creator A5045424861 @default.
- W4382397382 creator A5049301997 @default.
- W4382397382 creator A5056066703 @default.
- W4382397382 creator A5068346443 @default.
- W4382397382 creator A5083478186 @default.
- W4382397382 date "2023-06-28" @default.
- W4382397382 modified "2023-09-26" @default.
- W4382397382 title "Structural mechanism of heavy metal-associated integrated domain engineering of paired nucleotide-binding and leucine-rich repeat proteins in rice" @default.
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