Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382397750> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4382397750 endingPage "7413" @default.
- W4382397750 startingPage "7394" @default.
- W4382397750 abstract "Determination of terazosin hydrochloride dihydrate (TRZ) in drug substance and tablets was studied by potentiometeric and fluorimetric techniques. potentiometeric method has focused on the fabrication of two carbon paste ion selective electrodes for determination of the drug under investigation using potentiometric titration with phosphomolybdic acid (PMA), and Phosphotungestic acid (PTA). The influence of the electrode composition, conditioning time of the electrode and pH of the test solution, on the electrode performance were investigated. The drug electrode showed Nernstian response in the concentration range from 1x10-6-1xi0-2 mol L-1, 2×10-6-1×10-2 mol L-1 with slope of 58.4±0.35, and 57.3±0.23 mV decade-1 using PMA, and PTA respectively. It was found to be very precise and usable within the pH range 2-6. These sensors exhibited a low detection limit (8x10-7, 6x10-7 mol L-1). The fluorimetric methods are based on: (1) measurement of the native fluorescence of the drug in water at 750 nm after excitation at 330 nm. (2) sensitizing the native fluorescence by formation a binary complex of drug with aqueous uranyl acetate (0.1% w/v) at the same Ex / Em. under the described condition. the proposed methods were applicable over the concentration range of (10 -1000 and 0.5-12 ng mL-1) with good correlation ((r2=0.9982 and 0.9987), limit of detection of ( 3.47 and 0.198 ng/mL) and a lower limit of quantification of (10.5 and 0.6 ng mL-1) for method (1) and (2), respectively. The described methods were successfully applied for the determination of TRZ in its commercial tablets without interference from common excipients." @default.
- W4382397750 created "2023-06-29" @default.
- W4382397750 creator A5004769069 @default.
- W4382397750 creator A5054742695 @default.
- W4382397750 date "2014-12-01" @default.
- W4382397750 modified "2023-10-04" @default.
- W4382397750 title "Potentiometric and Fluorimetric Methods for the Determination of Terazosin HCl in Drug Substance and Dosage Forms" @default.
- W4382397750 cites W1972395317 @default.
- W4382397750 cites W1979318683 @default.
- W4382397750 cites W1980295788 @default.
- W4382397750 cites W2001245022 @default.
- W4382397750 cites W2008473878 @default.
- W4382397750 cites W2010104477 @default.
- W4382397750 cites W2020698838 @default.
- W4382397750 cites W2021574502 @default.
- W4382397750 cites W2024143975 @default.
- W4382397750 cites W2027013629 @default.
- W4382397750 cites W2032356710 @default.
- W4382397750 cites W2036134697 @default.
- W4382397750 cites W2039527098 @default.
- W4382397750 cites W2039963846 @default.
- W4382397750 cites W2053589627 @default.
- W4382397750 cites W2056407824 @default.
- W4382397750 cites W2063486880 @default.
- W4382397750 cites W2071773769 @default.
- W4382397750 cites W2075489519 @default.
- W4382397750 cites W2075496755 @default.
- W4382397750 cites W2077959005 @default.
- W4382397750 cites W2085730091 @default.
- W4382397750 cites W2177018729 @default.
- W4382397750 cites W2460077561 @default.
- W4382397750 cites W4301239399 @default.
- W4382397750 cites W4382134237 @default.
- W4382397750 cites W2035945111 @default.
- W4382397750 doi "https://doi.org/10.1016/s1452-3981(23)10976-x" @default.
- W4382397750 hasPublicationYear "2014" @default.
- W4382397750 type Work @default.
- W4382397750 citedByCount "3" @default.
- W4382397750 countsByYear W43823977502015 @default.
- W4382397750 countsByYear W43823977502018 @default.
- W4382397750 crossrefType "journal-article" @default.
- W4382397750 hasAuthorship W4382397750A5004769069 @default.
- W4382397750 hasAuthorship W4382397750A5054742695 @default.
- W4382397750 hasBestOaLocation W43823977501 @default.
- W4382397750 hasConcept C119128265 @default.
- W4382397750 hasConcept C121332964 @default.
- W4382397750 hasConcept C124614425 @default.
- W4382397750 hasConcept C13965031 @default.
- W4382397750 hasConcept C147789679 @default.
- W4382397750 hasConcept C17525397 @default.
- W4382397750 hasConcept C178790620 @default.
- W4382397750 hasConcept C184651966 @default.
- W4382397750 hasConcept C185592680 @default.
- W4382397750 hasConcept C43617362 @default.
- W4382397750 hasConcept C62520636 @default.
- W4382397750 hasConcept C91881484 @default.
- W4382397750 hasConceptScore W4382397750C119128265 @default.
- W4382397750 hasConceptScore W4382397750C121332964 @default.
- W4382397750 hasConceptScore W4382397750C124614425 @default.
- W4382397750 hasConceptScore W4382397750C13965031 @default.
- W4382397750 hasConceptScore W4382397750C147789679 @default.
- W4382397750 hasConceptScore W4382397750C17525397 @default.
- W4382397750 hasConceptScore W4382397750C178790620 @default.
- W4382397750 hasConceptScore W4382397750C184651966 @default.
- W4382397750 hasConceptScore W4382397750C185592680 @default.
- W4382397750 hasConceptScore W4382397750C43617362 @default.
- W4382397750 hasConceptScore W4382397750C62520636 @default.
- W4382397750 hasConceptScore W4382397750C91881484 @default.
- W4382397750 hasIssue "12" @default.
- W4382397750 hasLocation W43823977501 @default.
- W4382397750 hasOpenAccess W4382397750 @default.
- W4382397750 hasPrimaryLocation W43823977501 @default.
- W4382397750 hasRelatedWork W1989749748 @default.
- W4382397750 hasRelatedWork W2018716592 @default.
- W4382397750 hasRelatedWork W2030259291 @default.
- W4382397750 hasRelatedWork W2030531789 @default.
- W4382397750 hasRelatedWork W2087549700 @default.
- W4382397750 hasRelatedWork W2138486935 @default.
- W4382397750 hasRelatedWork W2481938601 @default.
- W4382397750 hasRelatedWork W2531510992 @default.
- W4382397750 hasRelatedWork W3138402746 @default.
- W4382397750 hasRelatedWork W2489749078 @default.
- W4382397750 hasVolume "9" @default.
- W4382397750 isParatext "false" @default.
- W4382397750 isRetracted "false" @default.
- W4382397750 workType "article" @default.