FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382398335> ?p ?o ?g. }

• W4382398335 endingPage "5595" @default.
• W4382398335 startingPage "5582" @default.
• W4382398335 abstract "Abstract The aberrant differentiation of osteoclasts is a key feature of the pathogenesis of osteoporosis, which has a devastating impact on human health. While the effects of Orientin (Ori) on osteoporosis, particularly on RANKL‐stimulated osteoclast production and activation, remain still unclear, Ori has been found to display several biological activities, including antioxidant and anti‐inflammatory. In this work, we investigated the possible pathways through which Ori suppressed RANKL‐induced osteoclast development and showed for the first time that it does so. The macrophages from the bone marrow (BMMs) were cultivated and then treated with Ori after being stimulated with RANKL. Then, TRAP‐positive multinucleated cells were counted, and F‐actin ring analysis was used to assess Ori's impact on mature osteoclast development. In addition, dihydroethidium (DHE) staining was used to evaluate the impact of Ori on RANKL‐induced reactive oxygen species (ROS). In addition, we performed western blotting and quantitative RT‐PCR analysis to investigate probable causes of these downregulation effects. We discovered that Ori inhibits the creation of osteoclasts, the gene and protein expressions unique to osteoclasts, and the ROS production. By activating Nrf2 and other ROS‐scavenging enzymes, Ori reduces intracellular ROS levels. The expression of the main transcription factor of osteoclast development, c‐Fos, was downregulated together with NFATc1, CTSK, and NFATc2, thanks to Ori's inhibition of RANKL‐induced NF‐κB. Consistent with its in vitro antiosteoclastogenic action, Ori therapy in the ovariectomized (OVX) rat model was also able to restore bone mass and improve microarchitecture in the distal femurs. Together, our results demonstrate that Ori is a flavonoid molecule with therapeutic promise for bone illnesses associated with osteoclasts, such as osteoporosis." @default.
• W4382398335 created "2023-06-29" @default.
• W4382398335 creator A5002459266 @default.
• W4382398335 creator A5015846827 @default.
• W4382398335 creator A5025121085 @default.
• W4382398335 creator A5029851581 @default.
• W4382398335 creator A5083078214 @default.
• W4382398335 creator A5083558362 @default.
• W4382398335 date "2023-06-28" @default.
• W4382398335 modified "2023-10-17" @default.
• W4382398335 title "Orientin suppresses osteoclastogenesis and ameliorates ovariectomy‐induced osteoporosis via suppressing ROS production" @default.
• W4382398335 cites W1735340376 @default.
• W4382398335 cites W1947390637 @default.
• W4382398335 cites W2090278215 @default.
• W4382398335 cites W2263772720 @default.
• W4382398335 cites W2324578291 @default.
• W4382398335 cites W2328967715 @default.
• W4382398335 cites W2407208812 @default.
• W4382398335 cites W2518942984 @default.
• W4382398335 cites W2714456978 @default.
• W4382398335 cites W2888067977 @default.
• W4382398335 cites W2923553556 @default.
• W4382398335 cites W2946387799 @default.
• W4382398335 cites W2946514715 @default.
• W4382398335 cites W2955907834 @default.
• W4382398335 cites W2956238533 @default.
• W4382398335 cites W2970714805 @default.
• W4382398335 cites W2975923821 @default.
• W4382398335 cites W3000616696 @default.
• W4382398335 cites W3004554410 @default.
• W4382398335 cites W3016455563 @default.
• W4382398335 cites W3021703239 @default.
• W4382398335 cites W3041919366 @default.
• W4382398335 cites W3047042685 @default.
• W4382398335 cites W3081156108 @default.
• W4382398335 cites W3081388871 @default.
• W4382398335 cites W3099127405 @default.
• W4382398335 cites W3104682346 @default.
• W4382398335 cites W3108270969 @default.
• W4382398335 cites W3120759974 @default.
• W4382398335 cites W4283268009 @default.
• W4382398335 cites W4297855331 @default.
• W4382398335 cites W4318669849 @default.
• W4382398335 doi "https://doi.org/10.1002/fsn3.3516" @default.
• W4382398335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37701239" @default.
• W4382398335 hasPublicationYear "2023" @default.
• W4382398335 type Work @default.
• W4382398335 citedByCount "0" @default.
• W4382398335 crossrefType "journal-article" @default.
• W4382398335 hasAuthorship W4382398335A5002459266 @default.
• W4382398335 hasAuthorship W4382398335A5015846827 @default.
• W4382398335 hasAuthorship W4382398335A5025121085 @default.
• W4382398335 hasAuthorship W4382398335A5029851581 @default.
• W4382398335 hasAuthorship W4382398335A5083078214 @default.
• W4382398335 hasAuthorship W4382398335A5083558362 @default.
• W4382398335 hasBestOaLocation W43823983351 @default.
• W4382398335 hasConcept C104317684 @default.
• W4382398335 hasConcept C126322002 @default.
• W4382398335 hasConcept C127561419 @default.
• W4382398335 hasConcept C134018914 @default.
• W4382398335 hasConcept C136403682 @default.
• W4382398335 hasConcept C170493617 @default.
• W4382398335 hasConcept C185592680 @default.
• W4382398335 hasConcept C202751555 @default.
• W4382398335 hasConcept C2776033226 @default.
• W4382398335 hasConcept C2776541429 @default.
• W4382398335 hasConcept C2779428903 @default.
• W4382398335 hasConcept C48349386 @default.
• W4382398335 hasConcept C502942594 @default.
• W4382398335 hasConcept C55493867 @default.
• W4382398335 hasConcept C71315377 @default.
• W4382398335 hasConcept C71924100 @default.
• W4382398335 hasConcept C8264082 @default.
• W4382398335 hasConcept C86803240 @default.
• W4382398335 hasConcept C88045685 @default.
• W4382398335 hasConcept C95444343 @default.
• W4382398335 hasConceptScore W4382398335C104317684 @default.
• W4382398335 hasConceptScore W4382398335C126322002 @default.
• W4382398335 hasConceptScore W4382398335C127561419 @default.
• W4382398335 hasConceptScore W4382398335C134018914 @default.
• W4382398335 hasConceptScore W4382398335C136403682 @default.
• W4382398335 hasConceptScore W4382398335C170493617 @default.
• W4382398335 hasConceptScore W4382398335C185592680 @default.
• W4382398335 hasConceptScore W4382398335C202751555 @default.
• W4382398335 hasConceptScore W4382398335C2776033226 @default.
• W4382398335 hasConceptScore W4382398335C2776541429 @default.
• W4382398335 hasConceptScore W4382398335C2779428903 @default.
• W4382398335 hasConceptScore W4382398335C48349386 @default.
• W4382398335 hasConceptScore W4382398335C502942594 @default.
• W4382398335 hasConceptScore W4382398335C55493867 @default.
• W4382398335 hasConceptScore W4382398335C71315377 @default.
• W4382398335 hasConceptScore W4382398335C71924100 @default.
• W4382398335 hasConceptScore W4382398335C8264082 @default.
• W4382398335 hasConceptScore W4382398335C86803240 @default.
• W4382398335 hasConceptScore W4382398335C88045685 @default.
• W4382398335 hasConceptScore W4382398335C95444343 @default.
• W4382398335 hasFunder F4320321001 @default.
• W4382398335 hasFunder F4320323159 @default.

• next