FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382400534> ?p ?o ?g. }

• W4382400534 abstract "Abstract Background This retrospective study aimed to characterize the distribution of HIV-1 genotypes and the prevalence of drug resistance mutations in people with antiretroviral treatment (ART) failure in Suzhou City, China. Methods Pol gene of HIV-1 viruses in blood samples of EDTA anticoagulants from 398 patients with failed antiviral treatment was successfully amplified by using an in-house assay. Drug resistance mutations were analyzed by using the Stanford HIV Drug Resistance Database system ( https://hivdb.stanford.edu/hivdb/by-mutations/ ). HIV-1 genotypes were determined by the REGA HIV subtyping tool (version 3.46, https://www.genomedetective.com/app/typingtool/hiv ). Near full-length genomes (NFLG) of HIV-1 viruses were obtained by next generation sequencing method. Results Sequences analysis of the pol gene revealed that CRF 01_AE (57.29%, 228/398) was the dominant subtype circulating in Suzhou City, followed by CRF 07_BC (17.34%, 69/398), subtype B (7.54%, 30/398), CRF 08_BC (6.53%, 26/398), CRF 67_01B (3.02%, 12/398) and CRF55_01B (2.51%, 10/398). The overall prevalence of drug-resistant mutations in cases with ART failure was 64.57% (257/398), including 45.48% (181/398) for nucleotide reverse transcriptase inhibitors (NRTIs) mutations, 63.32% (252/398) for non-nucleoside reverse transcriptase inhibitors (NNRTIs) mutations, and 3.02% (12/398) for protease inhibitors (PIs) mutations. Ten near full-length genomes (NFLG) of HIV-1 viruses were identified, including six recombinants of CRF 01_AE and subtype B, two recombinants of CRF 01_AE, subtype B and subtype C sequences, one recombinant of CRF 01_AE and subtype C and one recombinant of CRF 01_AE, subtype A1 and subtype C. Conclusions The high prevalence of drug-resistant HIV-1 viruses was a serious challenge for HIV prevention and treatment of people with HIV infection. Treatment regimens for ART failure patients should be adjusted over time based on the outcome of drug resistance tests. NFLG sequencing facilitates the identification of new recombinants of HIV-1." @default.
• W4382400534 created "2023-06-29" @default.
• W4382400534 creator A5003100965 @default.
• W4382400534 creator A5027566599 @default.
• W4382400534 creator A5035515939 @default.
• W4382400534 creator A5049352241 @default.
• W4382400534 creator A5052304130 @default.
• W4382400534 creator A5059802740 @default.
• W4382400534 creator A5066998474 @default.
• W4382400534 creator A5081520343 @default.
• W4382400534 date "2023-06-28" @default.
• W4382400534 modified "2023-10-18" @default.
• W4382400534 title "Genetic characterization of HIV-1 viruses among cases with antiretroviral therapy failure in Suzhou City, China" @default.
• W4382400534 cites W1541395592 @default.
• W4382400534 cites W2094726001 @default.
• W4382400534 cites W2159181197 @default.
• W4382400534 cites W2185029798 @default.
• W4382400534 cites W2194305182 @default.
• W4382400534 cites W2538502600 @default.
• W4382400534 cites W2582767837 @default.
• W4382400534 cites W2614294198 @default.
• W4382400534 cites W2791746780 @default.
• W4382400534 cites W2794600917 @default.
• W4382400534 cites W2798117401 @default.
• W4382400534 cites W2807354225 @default.
• W4382400534 cites W2889612530 @default.
• W4382400534 cites W2903314774 @default.
• W4382400534 cites W2908643789 @default.
• W4382400534 cites W2908647067 @default.
• W4382400534 cites W2921590137 @default.
• W4382400534 cites W2924309353 @default.
• W4382400534 cites W2936525131 @default.
• W4382400534 cites W2940654181 @default.
• W4382400534 cites W2943070672 @default.
• W4382400534 cites W2954434450 @default.
• W4382400534 cites W2997992062 @default.
• W4382400534 cites W2998394393 @default.
• W4382400534 cites W3006811239 @default.
• W4382400534 cites W3007106149 @default.
• W4382400534 cites W3012315384 @default.
• W4382400534 cites W3040788964 @default.
• W4382400534 cites W3131937589 @default.
• W4382400534 cites W3156744988 @default.
• W4382400534 cites W3207867092 @default.
• W4382400534 cites W4206084342 @default.
• W4382400534 cites W4247808616 @default.
• W4382400534 cites W4288066909 @default.
• W4382400534 cites W4289203483 @default.
• W4382400534 doi "https://doi.org/10.1186/s12981-023-00540-0" @default.
• W4382400534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37381002" @default.
• W4382400534 hasPublicationYear "2023" @default.
• W4382400534 type Work @default.
• W4382400534 citedByCount "0" @default.
• W4382400534 crossrefType "journal-article" @default.
• W4382400534 hasAuthorship W4382400534A5003100965 @default.
• W4382400534 hasAuthorship W4382400534A5027566599 @default.
• W4382400534 hasAuthorship W4382400534A5035515939 @default.
• W4382400534 hasAuthorship W4382400534A5049352241 @default.
• W4382400534 hasAuthorship W4382400534A5052304130 @default.
• W4382400534 hasAuthorship W4382400534A5059802740 @default.
• W4382400534 hasAuthorship W4382400534A5066998474 @default.
• W4382400534 hasAuthorship W4382400534A5081520343 @default.
• W4382400534 hasBestOaLocation W43824005341 @default.
• W4382400534 hasConcept C104317684 @default.
• W4382400534 hasConcept C114851261 @default.
• W4382400534 hasConcept C135763542 @default.
• W4382400534 hasConcept C142462285 @default.
• W4382400534 hasConcept C156719811 @default.
• W4382400534 hasConcept C159047783 @default.
• W4382400534 hasConcept C199360897 @default.
• W4382400534 hasConcept C2909970146 @default.
• W4382400534 hasConcept C2993143319 @default.
• W4382400534 hasConcept C3013748606 @default.
• W4382400534 hasConcept C41008148 @default.
• W4382400534 hasConcept C49105822 @default.
• W4382400534 hasConcept C54355233 @default.
• W4382400534 hasConcept C71924100 @default.
• W4382400534 hasConcept C83852419 @default.
• W4382400534 hasConcept C86803240 @default.
• W4382400534 hasConceptScore W4382400534C104317684 @default.
• W4382400534 hasConceptScore W4382400534C114851261 @default.
• W4382400534 hasConceptScore W4382400534C135763542 @default.
• W4382400534 hasConceptScore W4382400534C142462285 @default.
• W4382400534 hasConceptScore W4382400534C156719811 @default.
• W4382400534 hasConceptScore W4382400534C159047783 @default.
• W4382400534 hasConceptScore W4382400534C199360897 @default.
• W4382400534 hasConceptScore W4382400534C2909970146 @default.
• W4382400534 hasConceptScore W4382400534C2993143319 @default.
• W4382400534 hasConceptScore W4382400534C3013748606 @default.
• W4382400534 hasConceptScore W4382400534C41008148 @default.
• W4382400534 hasConceptScore W4382400534C49105822 @default.
• W4382400534 hasConceptScore W4382400534C54355233 @default.
• W4382400534 hasConceptScore W4382400534C71924100 @default.
• W4382400534 hasConceptScore W4382400534C83852419 @default.
• W4382400534 hasConceptScore W4382400534C86803240 @default.
• W4382400534 hasIssue "1" @default.
• W4382400534 hasLocation W43824005341 @default.
• W4382400534 hasLocation W43824005342 @default.
• W4382400534 hasLocation W43824005343 @default.
• W4382400534 hasOpenAccess W4382400534 @default.

• next