Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382401345> ?p ?o ?g. }
- W4382401345 endingPage "106841" @default.
- W4382401345 startingPage "106841" @default.
- W4382401345 abstract "Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling molecules that poison surrounding cells, leading to various age-related diseases, including diabetes, atherosclerosis, and Alzheimer's disease. The underlying mechanism of cellular senescence has not yet been fully explored. Emerging evidence indicates that hypoxia is involved in the regulation of cellular senescence. Hypoxia-inducible factor (HIF)- 1α accumulates under hypoxic conditions and regulates cellular senescence by modulating the levels of the senescence markers p16, p53, lamin B1, and cyclin D1. Hypoxia is a critical condition for maintaining tumor immune evasion, which is promoted by driving the expression of genetic factors (such as p53 and CD47) while triggering immunosenescence. Under hypoxic conditions, autophagy is activated by targeting BCL-2/adenovirus E1B 19-kDa interacting protein 3, which subsequently induces p21WAF1/CIP1 as well as p16Ink4a and increases β-galactosidase (β-gal) activity, thereby inducing cellular senescence. Deletion of the p21 gene increases the activity of the hypoxia response regulator poly (ADP-ribose) polymerase-1 (PARP-1) and the level of nonhomologous end joining (NHEJ) proteins, repairs DNA double-strand breaks, and alleviates cellular senescence. Moreover, cellular senescence is associated with intestinal dysbiosis and an accumulation of D-galactose derived from the gut microbiota. Chronic hypoxia leads to a striking reduction in the amount of Lactobacillus and D-galactose-degrading enzymes in the gut, producing excess reactive oxygen species (ROS) and inducing senescence in bone marrow mesenchymal stem cells. Exosomal microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) play important roles in cellular senescence. miR-424-5p levels are decreased under hypoxia, whereas lncRNA-MALAT1 levels are increased, both of which induce cellular senescence. The present review focuses on recent advances in understanding the role of hypoxia in cellular senescence. The effects of HIFs, immune evasion, PARP-1, gut microbiota, and exosomal mRNA in hypoxia-mediated cell senescence are specifically discussed. This review increases our understanding of the mechanism of hypoxia-mediated cellular senescence and provides new clues for anti-aging processes and the treatment of aging-related diseases." @default.
- W4382401345 created "2023-06-29" @default.
- W4382401345 creator A5001097432 @default.
- W4382401345 creator A5006376053 @default.
- W4382401345 creator A5013987157 @default.
- W4382401345 creator A5018934612 @default.
- W4382401345 creator A5029102942 @default.
- W4382401345 creator A5062654380 @default.
- W4382401345 creator A5066903927 @default.
- W4382401345 date "2023-08-01" @default.
- W4382401345 modified "2023-10-15" @default.
- W4382401345 title "Role of hypoxia in cellular senescence" @default.
- W4382401345 cites W1514420217 @default.
- W4382401345 cites W1517713315 @default.
- W4382401345 cites W1527152862 @default.
- W4382401345 cites W181556572 @default.
- W4382401345 cites W1853160207 @default.
- W4382401345 cites W1926062985 @default.
- W4382401345 cites W1940501747 @default.
- W4382401345 cites W1950865010 @default.
- W4382401345 cites W1965703240 @default.
- W4382401345 cites W1968593031 @default.
- W4382401345 cites W1970891016 @default.
- W4382401345 cites W1974475104 @default.
- W4382401345 cites W1976531450 @default.
- W4382401345 cites W1987824810 @default.
- W4382401345 cites W1990461051 @default.
- W4382401345 cites W1997567430 @default.
- W4382401345 cites W1997732325 @default.
- W4382401345 cites W1998862888 @default.
- W4382401345 cites W1999872096 @default.
- W4382401345 cites W2001675597 @default.
- W4382401345 cites W2001733842 @default.
- W4382401345 cites W2004053427 @default.
- W4382401345 cites W2005248738 @default.
- W4382401345 cites W2010417927 @default.
- W4382401345 cites W2012561030 @default.
- W4382401345 cites W2017844161 @default.
- W4382401345 cites W2023279756 @default.
- W4382401345 cites W2037623985 @default.
- W4382401345 cites W2040414192 @default.
- W4382401345 cites W2047394764 @default.
- W4382401345 cites W2052548727 @default.
- W4382401345 cites W2056977252 @default.
- W4382401345 cites W2058045514 @default.
- W4382401345 cites W2061619522 @default.
- W4382401345 cites W2063142571 @default.
- W4382401345 cites W2069641472 @default.
- W4382401345 cites W2071361463 @default.
- W4382401345 cites W2073144071 @default.
- W4382401345 cites W2075602298 @default.
- W4382401345 cites W2078967065 @default.
- W4382401345 cites W2080100430 @default.
- W4382401345 cites W2090314062 @default.
- W4382401345 cites W2090551452 @default.
- W4382401345 cites W2092658747 @default.
- W4382401345 cites W2096374511 @default.
- W4382401345 cites W2096587251 @default.
- W4382401345 cites W2100864963 @default.
- W4382401345 cites W2103214055 @default.
- W4382401345 cites W2103735571 @default.
- W4382401345 cites W2108358002 @default.
- W4382401345 cites W2111725588 @default.
- W4382401345 cites W2112058575 @default.
- W4382401345 cites W2113995129 @default.
- W4382401345 cites W2116054786 @default.
- W4382401345 cites W2125663719 @default.
- W4382401345 cites W2126525177 @default.
- W4382401345 cites W2128147036 @default.
- W4382401345 cites W2128488659 @default.
- W4382401345 cites W2130218225 @default.
- W4382401345 cites W2132406938 @default.
- W4382401345 cites W2136331786 @default.
- W4382401345 cites W2140930678 @default.
- W4382401345 cites W2156255024 @default.
- W4382401345 cites W2158535498 @default.
- W4382401345 cites W2159279413 @default.
- W4382401345 cites W2161312917 @default.
- W4382401345 cites W2164188362 @default.
- W4382401345 cites W2168774749 @default.
- W4382401345 cites W2211872530 @default.
- W4382401345 cites W2226806579 @default.
- W4382401345 cites W2235214586 @default.
- W4382401345 cites W2237167759 @default.
- W4382401345 cites W2350256796 @default.
- W4382401345 cites W2395207553 @default.
- W4382401345 cites W2441644746 @default.
- W4382401345 cites W2472675502 @default.
- W4382401345 cites W2527089560 @default.
- W4382401345 cites W2529277290 @default.
- W4382401345 cites W2529677616 @default.
- W4382401345 cites W2555863076 @default.
- W4382401345 cites W2580377014 @default.
- W4382401345 cites W2592615787 @default.
- W4382401345 cites W2602344822 @default.
- W4382401345 cites W2607005708 @default.
- W4382401345 cites W2613239826 @default.
- W4382401345 cites W2732024516 @default.