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- W4382403909 abstract "Abstract Legionella pneumophila grows within host cells by forming a specialized membrane-bound compartment via the Icm/Dot type IV secretion system (T4SS). T4SS translocated Sde proteins promote phosphoribosyl-linked ubiquitination (pR-Ub) of several mammalian cell proteins, including Rtn4. In response to modification, Rtn4 forms tubular ER aggregates around the Legionella- containing vacuole (LCV). The loss of sde together with sdhA results in severe vacuole disruption at early infection timepoints. We tested if Rtn4 modification allowed it to serve as a physical barrier to protect its degradation from host-derived disruptive compartments. The challenge of the rtn4 -/- macrophages with Δ sdhA partially phenocopied the challenge of rtn4 +/+ with Δ sde Δ sdhA , indicating that Rtn4 plays a role in protecting LCV integrity. Depletion of rtn1 in rtn4 -/- macrophages potentiated vacuole permeability when compared to rtn4 -/- macrophages, consistent with Sde targeting multiple reticulon family members to support vacuole integrity. These results indicate that L. pneumophila exploits Rtn4 in cooperation with Rtn1 to establish a replication niche by promoting Sde-mediated tubular ER aggregates, arguing that these proteins function as a physical barrier during early steps of LCV biogenesis." @default.
- W4382403909 created "2023-06-29" @default.
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- W4382403909 date "2023-06-27" @default.
- W4382403909 modified "2023-09-28" @default.
- W4382403909 title "The Sde phosphoribosyl-linked ubiquitin transferases exploit reticulons to protect the integrity of the<i>Legionella</i>-containing vacuole" @default.
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- W4382403909 doi "https://doi.org/10.1101/2023.06.27.546723" @default.
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