FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382467029> ?p ?o ?g. }

• W4382467029 abstract "Hypothesis: Asbestos-driven inflammation contributes to malignant pleural mesothelioma beyond the acquisition of rate-limiting mutations. Methods: Genetically modified conditional allelic mice that were previously shown to develop mesothelioma in the absence of exposure to asbestos were induced with lentiviral vector expressing Cre recombinase with and without intrapleural injection of amosite asbestos and monitored until symptoms required euthanasia. Resulting tumours were examined histologically and by immunohistochemistry for expression of lineage markers and immune cell infiltration. Results: Injection of asbestos dramatically accelerated disease onset and end-stage tumour burden. Tumours developed in the presence of asbestos showed increased macrophage infiltration. Pharmacological suppression of macrophages in mice with established tumours failed to extend survival or to enhance response to chemotherapy. Conclusion: Asbestos-driven inflammation contributes to the severity of mesothelioma beyond the acquisition of rate-limiting mutations, however, targeted suppression of macrophages in established epithelioid mesothelioma showed no therapeutic benefit." @default.
• W4382467029 created "2023-06-29" @default.
• W4382467029 creator A5006103612 @default.
• W4382467029 creator A5012575170 @default.
• W4382467029 creator A5034035769 @default.
• W4382467029 creator A5038206833 @default.
• W4382467029 creator A5045454610 @default.
• W4382467029 creator A5056130118 @default.
• W4382467029 creator A5056815394 @default.
• W4382467029 creator A5057031525 @default.
• W4382467029 creator A5057588719 @default.
• W4382467029 creator A5059555012 @default.
• W4382467029 creator A5067662754 @default.
• W4382467029 creator A5068505111 @default.
• W4382467029 creator A5073356995 @default.
• W4382467029 creator A5076001607 @default.
• W4382467029 creator A5076554539 @default.
• W4382467029 creator A5078029398 @default.
• W4382467029 creator A5079822404 @default.
• W4382467029 creator A5088998967 @default.
• W4382467029 date "2023-06-27" @default.
• W4382467029 modified "2023-10-16" @default.
• W4382467029 title "Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma" @default.
• W4382467029 cites W1691015430 @default.
• W4382467029 cites W1973094248 @default.
• W4382467029 cites W1978135247 @default.
• W4382467029 cites W1998543226 @default.
• W4382467029 cites W2003223749 @default.
• W4382467029 cites W2024678706 @default.
• W4382467029 cites W2026878412 @default.
• W4382467029 cites W2028058888 @default.
• W4382467029 cites W2037306309 @default.
• W4382467029 cites W2042328755 @default.
• W4382467029 cites W2061123122 @default.
• W4382467029 cites W2067423716 @default.
• W4382467029 cites W2073301230 @default.
• W4382467029 cites W2102278945 @default.
• W4382467029 cites W2112004317 @default.
• W4382467029 cites W2134526812 @default.
• W4382467029 cites W2138003976 @default.
• W4382467029 cites W2150706412 @default.
• W4382467029 cites W2151199834 @default.
• W4382467029 cites W2160275284 @default.
• W4382467029 cites W2165750757 @default.
• W4382467029 cites W2179438025 @default.
• W4382467029 cites W2280299238 @default.
• W4382467029 cites W2284919534 @default.
• W4382467029 cites W2291531085 @default.
• W4382467029 cites W2500721338 @default.
• W4382467029 cites W2527738828 @default.
• W4382467029 cites W2559224373 @default.
• W4382467029 cites W2765676749 @default.
• W4382467029 cites W2766967575 @default.
• W4382467029 cites W2767787155 @default.
• W4382467029 cites W2768201638 @default.
• W4382467029 cites W2795441802 @default.
• W4382467029 cites W2795557894 @default.
• W4382467029 cites W2799476413 @default.
• W4382467029 cites W2804535713 @default.
• W4382467029 cites W2890271012 @default.
• W4382467029 cites W2892837443 @default.
• W4382467029 cites W2897299514 @default.
• W4382467029 cites W2909198142 @default.
• W4382467029 cites W2911913633 @default.
• W4382467029 cites W2924341172 @default.
• W4382467029 cites W2945653463 @default.
• W4382467029 cites W2947324713 @default.
• W4382467029 cites W2952481429 @default.
• W4382467029 cites W2953590471 @default.
• W4382467029 cites W2961490246 @default.
• W4382467029 cites W2974545606 @default.
• W4382467029 cites W3011578554 @default.
• W4382467029 cites W3016162437 @default.
• W4382467029 cites W3035680703 @default.
• W4382467029 cites W3090453482 @default.
• W4382467029 cites W3136769797 @default.
• W4382467029 cites W3170903966 @default.
• W4382467029 cites W3188281451 @default.
• W4382467029 cites W3202252201 @default.
• W4382467029 cites W3213716658 @default.
• W4382467029 cites W4205944471 @default.
• W4382467029 cites W4281721830 @default.
• W4382467029 cites W4290621813 @default.
• W4382467029 cites W4312083384 @default.
• W4382467029 cites W4327568939 @default.
• W4382467029 doi "https://doi.org/10.3389/ftox.2023.1200650" @default.
• W4382467029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37441092" @default.
• W4382467029 hasPublicationYear "2023" @default.
• W4382467029 type Work @default.
• W4382467029 citedByCount "0" @default.
• W4382467029 crossrefType "journal-article" @default.
• W4382467029 hasAuthorship W4382467029A5006103612 @default.
• W4382467029 hasAuthorship W4382467029A5012575170 @default.
• W4382467029 hasAuthorship W4382467029A5034035769 @default.
• W4382467029 hasAuthorship W4382467029A5038206833 @default.
• W4382467029 hasAuthorship W4382467029A5045454610 @default.
• W4382467029 hasAuthorship W4382467029A5056130118 @default.
• W4382467029 hasAuthorship W4382467029A5056815394 @default.
• W4382467029 hasAuthorship W4382467029A5057031525 @default.
• W4382467029 hasAuthorship W4382467029A5057588719 @default.

• next