FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382501244> ?p ?o ?g. }

• W4382501244 abstract "Background: Cerebral edema is a secondary complication of acute ischemic stroke, but its time course and imaging markers are not fully understood. Recently, net water uptake (NWU) has been proposed as a novel marker of edema. Aims: Studying the RHAPSODY trial cohort, we sought to characterize the time course of edema and test the hypothesis that NWU provides distinct information when added to traditional markers of cerebral edema after stroke by examining its association with other markers. Methods: A total of 65 patients had measurable supratentorial ischemic lesions. Patients underwent head computed tomography (CT), brain magnetic resonance imaging (MRI) scans, or both at the baseline visit and after 2, 7, 30, and 90 days following enrollment. CT and MRI scans were used to measure four imaging markers of edema: midline shift (MLS), hemisphere volume ratio (HVR), cerebrospinal fluid (CSF) volume, and NWU using semi-quantitative threshold analysis. Trajectories of the markers were summarized, as available. Correlations of the markers of edema were computed and the markers compared by clinical outcome. Regression models were used to examine the effect of 3K3A-activated protein C (APC) treatment. Results: Two measures of mass effect, MLS and HVR, could be measured on all imaging modalities, and had values available across all time points. Accordingly, mass effect reached a maximum level by day 7, normalized by day 30, and then reversed by day 90 for both measures. In the first 2 days after stroke, the change in CSF volume was associated with MLS (ρ = –0.57, p = 0.0001) and HVR (ρ = –0.66, p < 0.0001). In contrast, the change in NWU was not associated with the other imaging markers (all p ⩾ 0.49). While being directionally consistent, we did not observe a difference in the edema markers by clinical outcome. In addition, baseline stroke volume was associated with all markers (MLS ( p < 0.001), HVR ( p < 0.001), change in CSF volume ( p = 0.003)) with the exception of NWU ( p = 0.5). Exploratory analysis did not reveal a difference in cerebral edema markers by treatment arm. Conclusions: Existing cerebral edema imaging markers potentially describe two distinct processes, including lesional water concentration (i.e. NWU) and mass effect (MLS, HVR, and CSF volume). These two types of imaging markers may represent distinct aspects of cerebral edema, which could be useful for future trials targeting this process." @default.
• W4382501244 created "2023-06-30" @default.
• W4382501244 creator A5019226814 @default.
• W4382501244 creator A5024676890 @default.
• W4382501244 creator A5027887363 @default.
• W4382501244 creator A5033294389 @default.
• W4382501244 creator A5036566811 @default.
• W4382501244 creator A5040967520 @default.
• W4382501244 creator A5043406101 @default.
• W4382501244 creator A5057158115 @default.
• W4382501244 creator A5072490641 @default.
• W4382501244 creator A5074207991 @default.
• W4382501244 creator A5082223284 @default.
• W4382501244 creator A5086474167 @default.
• W4382501244 creator A5087404698 @default.
• W4382501244 creator A5088051577 @default.
• W4382501244 creator A5088307261 @default.
• W4382501244 date "2023-07-16" @default.
• W4382501244 modified "2023-10-18" @default.
• W4382501244 title "Analysis of brain edema in RHAPSODY" @default.
• W4382501244 cites W1927888013 @default.
• W4382501244 cites W1968133365 @default.
• W4382501244 cites W1978768653 @default.
• W4382501244 cites W2014169570 @default.
• W4382501244 cites W2094744578 @default.
• W4382501244 cites W2105443363 @default.
• W4382501244 cites W2162580040 @default.
• W4382501244 cites W2338475921 @default.
• W4382501244 cites W2518303214 @default.
• W4382501244 cites W2542414179 @default.
• W4382501244 cites W2547471541 @default.
• W4382501244 cites W2555151154 @default.
• W4382501244 cites W2804011875 @default.
• W4382501244 cites W2808625119 @default.
• W4382501244 cites W2826458956 @default.
• W4382501244 cites W2901086519 @default.
• W4382501244 cites W2974096166 @default.
• W4382501244 cites W2995456349 @default.
• W4382501244 cites W3046167359 @default.
• W4382501244 cites W3196695474 @default.
• W4382501244 cites W4224210584 @default.
• W4382501244 doi "https://doi.org/10.1177/17474930231187268" @default.
• W4382501244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37382409" @default.
• W4382501244 hasPublicationYear "2023" @default.
• W4382501244 type Work @default.
• W4382501244 citedByCount "0" @default.
• W4382501244 crossrefType "journal-article" @default.
• W4382501244 hasAuthorship W4382501244A5019226814 @default.
• W4382501244 hasAuthorship W4382501244A5024676890 @default.
• W4382501244 hasAuthorship W4382501244A5027887363 @default.
• W4382501244 hasAuthorship W4382501244A5033294389 @default.
• W4382501244 hasAuthorship W4382501244A5036566811 @default.
• W4382501244 hasAuthorship W4382501244A5040967520 @default.
• W4382501244 hasAuthorship W4382501244A5043406101 @default.
• W4382501244 hasAuthorship W4382501244A5057158115 @default.
• W4382501244 hasAuthorship W4382501244A5072490641 @default.
• W4382501244 hasAuthorship W4382501244A5074207991 @default.
• W4382501244 hasAuthorship W4382501244A5082223284 @default.
• W4382501244 hasAuthorship W4382501244A5086474167 @default.
• W4382501244 hasAuthorship W4382501244A5087404698 @default.
• W4382501244 hasAuthorship W4382501244A5088051577 @default.
• W4382501244 hasAuthorship W4382501244A5088307261 @default.
• W4382501244 hasConcept C126322002 @default.
• W4382501244 hasConcept C126838900 @default.
• W4382501244 hasConcept C127413603 @default.
• W4382501244 hasConcept C142724271 @default.
• W4382501244 hasConcept C143409427 @default.
• W4382501244 hasConcept C2777318445 @default.
• W4382501244 hasConcept C2779493303 @default.
• W4382501244 hasConcept C2780645631 @default.
• W4382501244 hasConcept C2780886150 @default.
• W4382501244 hasConcept C2989005 @default.
• W4382501244 hasConcept C544519230 @default.
• W4382501244 hasConcept C71924100 @default.
• W4382501244 hasConcept C78519656 @default.
• W4382501244 hasConceptScore W4382501244C126322002 @default.
• W4382501244 hasConceptScore W4382501244C126838900 @default.
• W4382501244 hasConceptScore W4382501244C127413603 @default.
• W4382501244 hasConceptScore W4382501244C142724271 @default.
• W4382501244 hasConceptScore W4382501244C143409427 @default.
• W4382501244 hasConceptScore W4382501244C2777318445 @default.
• W4382501244 hasConceptScore W4382501244C2779493303 @default.
• W4382501244 hasConceptScore W4382501244C2780645631 @default.
• W4382501244 hasConceptScore W4382501244C2780886150 @default.
• W4382501244 hasConceptScore W4382501244C2989005 @default.
• W4382501244 hasConceptScore W4382501244C544519230 @default.
• W4382501244 hasConceptScore W4382501244C71924100 @default.
• W4382501244 hasConceptScore W4382501244C78519656 @default.
• W4382501244 hasFunder F4320332161 @default.
• W4382501244 hasFunder F4320337359 @default.
• W4382501244 hasLocation W43825012441 @default.
• W4382501244 hasLocation W43825012442 @default.
• W4382501244 hasOpenAccess W4382501244 @default.
• W4382501244 hasPrimaryLocation W43825012441 @default.
• W4382501244 hasRelatedWork W112004381 @default.
• W4382501244 hasRelatedWork W1927888013 @default.
• W4382501244 hasRelatedWork W1967290285 @default.
• W4382501244 hasRelatedWork W2042325978 @default.
• W4382501244 hasRelatedWork W2144995224 @default.
• W4382501244 hasRelatedWork W2348158266 @default.

• next