FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382502017> ?p ?o ?g. }

• W4382502017 abstract "Introduction. Combination of PCR and Elek testing to identify toxigenic corynebacteria has revealed organisms described as non-toxigenic toxin-gene bearing (NTTB) Corynebacterium diphtheriae or C. ulcerans (i.e. PCR tox positive; Elek negative). These organisms carry part or all of tox , but are unable to express diphtheria toxin (DT) and present a challenge to clinical and public health case management. Gap analysis/Hypothesis. There are few data on the theoretical risk of NTTB reversion to toxigenicity. This unique cluster and subsequent epidemiologically linked isolates allowed the opportunity to determine any change in DT expression status. Aim. To characterize a cluster of infections due to NTTB in a skin clinic and subsequent cases in two household contacts. Methodology. Epidemiological and microbiological investigations were carried out according to existing national guidance at the time. Susceptibility testing used gradient strips. The tox operon analysis and multi-locus sequence typing (MLST) was derived from whole-genome sequencing. Alignment of the tox operon and phylogenetic analyses were performed using clustalW, mega , the public core-genome MLST (cgMLST) scheme and an in-house bioinformatic single nucleotide polymorphism (SNP) typing pipeline. Results. Isolates of NTTB C. diphtheriae were recovered from four cases (cases 1 to 4) with epidermolysis bullosa attending the clinic. Two further isolates were subsequently recovered from case 4, >18 months later, and from two household contacts (cases 5 and 6) after a further 18 months and 3.5 years, respectively. All eight strains were NTTB C. diphtheriae biovar mitis, belonged to the same sequence type (ST-336) with the same deletion in tox . Phylogenetic analysis showed relatively high diversity between the eight strains with 7–199 SNP and 3–109 cgMLST loci differences between them. The number of SNPs between the three isolates from case 4 and two household contacts (cases 5 and 6) was 44–70 with 28–38 cgMLST loci differences. Conclusions. We report a cluster of NTTB C. diphtheriae cases in a skin clinic and evidence of onward household transmission. We conclude the deletion in the tox was responsible for the non-expression of DT. There was no evidence of reversion to DT expression over the 6.5 year period studied. These data informed revision to guidance in the management of NTTB cases and their contacts in the UK." @default.
• W4382502017 created "2023-06-30" @default.
• W4382502017 creator A5001896873 @default.
• W4382502017 creator A5002177876 @default.
• W4382502017 creator A5008173791 @default.
• W4382502017 creator A5012805826 @default.
• W4382502017 creator A5027428397 @default.
• W4382502017 creator A5036002948 @default.
• W4382502017 creator A5044996506 @default.
• W4382502017 creator A5045650593 @default.
• W4382502017 creator A5050074242 @default.
• W4382502017 creator A5052449898 @default.
• W4382502017 creator A5057229195 @default.
• W4382502017 creator A5060928677 @default.
• W4382502017 creator A5064745227 @default.
• W4382502017 creator A5065097521 @default.
• W4382502017 creator A5067682457 @default.
• W4382502017 creator A5072769747 @default.
• W4382502017 creator A5074638608 @default.
• W4382502017 creator A5078490910 @default.
• W4382502017 creator A5086467750 @default.
• W4382502017 creator A5092356086 @default.
• W4382502017 date "2023-06-29" @default.
• W4382502017 modified "2023-10-08" @default.
• W4382502017 title "Household transmission of non-toxigenic diphtheria toxin gene-bearing Corynebacterium diphtheriae following a cluster of cutaneous cases in a specialist outpatient setting" @default.
• W4382502017 cites W1473022311 @default.
• W4382502017 cites W1512635407 @default.
• W4382502017 cites W1973315214 @default.
• W4382502017 cites W1976274900 @default.
• W4382502017 cites W2006134278 @default.
• W4382502017 cites W2017957371 @default.
• W4382502017 cites W2033346823 @default.
• W4382502017 cites W2075459696 @default.
• W4382502017 cites W2077242258 @default.
• W4382502017 cites W2092992202 @default.
• W4382502017 cites W2095787840 @default.
• W4382502017 cites W2096093282 @default.
• W4382502017 cites W2106882534 @default.
• W4382502017 cites W2110316236 @default.
• W4382502017 cites W2110558072 @default.
• W4382502017 cites W2114850508 @default.
• W4382502017 cites W2115342899 @default.
• W4382502017 cites W2121124040 @default.
• W4382502017 cites W2126968732 @default.
• W4382502017 cites W2142678478 @default.
• W4382502017 cites W2151670061 @default.
• W4382502017 cites W2151863305 @default.
• W4382502017 cites W2159624867 @default.
• W4382502017 cites W2171876483 @default.
• W4382502017 cites W2321103866 @default.
• W4382502017 cites W2339419120 @default.
• W4382502017 cites W2520501427 @default.
• W4382502017 cites W2546683862 @default.
• W4382502017 cites W2559516238 @default.
• W4382502017 cites W2559952647 @default.
• W4382502017 cites W2568059736 @default.
• W4382502017 cites W2768017947 @default.
• W4382502017 cites W2768356178 @default.
• W4382502017 cites W2799524357 @default.
• W4382502017 cites W2891078715 @default.
• W4382502017 cites W2893318426 @default.
• W4382502017 cites W2908670099 @default.
• W4382502017 cites W2952167528 @default.
• W4382502017 cites W2972251513 @default.
• W4382502017 cites W2999870303 @default.
• W4382502017 cites W3011024665 @default.
• W4382502017 cites W3046842481 @default.
• W4382502017 cites W3108864675 @default.
• W4382502017 cites W3111022417 @default.
• W4382502017 cites W4321365878 @default.
• W4382502017 doi "https://doi.org/10.1099/jmm.0.001722" @default.
• W4382502017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37384376" @default.
• W4382502017 hasPublicationYear "2023" @default.
• W4382502017 type Work @default.
• W4382502017 citedByCount "0" @default.
• W4382502017 crossrefType "journal-article" @default.
• W4382502017 hasAuthorship W4382502017A5001896873 @default.
• W4382502017 hasAuthorship W4382502017A5002177876 @default.
• W4382502017 hasAuthorship W4382502017A5008173791 @default.
• W4382502017 hasAuthorship W4382502017A5012805826 @default.
• W4382502017 hasAuthorship W4382502017A5027428397 @default.
• W4382502017 hasAuthorship W4382502017A5036002948 @default.
• W4382502017 hasAuthorship W4382502017A5044996506 @default.
• W4382502017 hasAuthorship W4382502017A5045650593 @default.
• W4382502017 hasAuthorship W4382502017A5050074242 @default.
• W4382502017 hasAuthorship W4382502017A5052449898 @default.
• W4382502017 hasAuthorship W4382502017A5057229195 @default.
• W4382502017 hasAuthorship W4382502017A5060928677 @default.
• W4382502017 hasAuthorship W4382502017A5064745227 @default.
• W4382502017 hasAuthorship W4382502017A5065097521 @default.
• W4382502017 hasAuthorship W4382502017A5067682457 @default.
• W4382502017 hasAuthorship W4382502017A5072769747 @default.
• W4382502017 hasAuthorship W4382502017A5074638608 @default.
• W4382502017 hasAuthorship W4382502017A5078490910 @default.
• W4382502017 hasAuthorship W4382502017A5086467750 @default.
• W4382502017 hasAuthorship W4382502017A5092356086 @default.
• W4382502017 hasConcept C104317684 @default.
• W4382502017 hasConcept C135763542 @default.
• W4382502017 hasConcept C159047783 @default.
• W4382502017 hasConcept C203075996 @default.

• next