FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382502185> ?p ?o ?g. }

• W4382502185 abstract "Abstract Background Pharmacological treatments are very common to be used for alleviating neuropsychiatric symptoms (NPS) in dementia. However, decision on drug selection is still a matter of controversy. Aims To summarise the comparative efficacy and acceptability of currently available monotherapy drug regimens for reducing NPS in dementia. Method We searched PubMed, MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials between inception and 26 December 2022 without language restrictions; and reference lists scanned from selected studies and systematic reviews. Double-blind randomised controlled trials were identified from electronic databases for reporting NPS outcomes in people with dementia. Primary outcomes were efficacy and acceptability. Confidence in the evidence was assessed using Confidence in Network Meta-Analysis (CINeMA). Results We included 59 trials (15,781 participants; mean age, 76.6 years) and 15 different drugs in quantitative syntheses. Risperidone (standardised mean difference [SMD] −0.20, 95% credible interval [CrI] −0.40 to −0.10) and galantamine (−0.20, −0.39 to −0.02) were more effective than placebo in short-term treatment (median duration: 12 weeks). Galantamine (odds ratio [OR] 1.95, 95% CrI 1.38–2.94) and rivastigmine (1.87, 1.24–2.99) were associated with more dropouts than placebo, and some active drugs. Most of the results were rated as low or very low according to CINeMA. Conclusions Despite the scarcity of high-quality evidence, risperidone is probably the best pharmacological option to consider for alleviating NPS in people with dementia in short-term treatment when considering the risk–benefit profile of drugs." @default.
• W4382502185 created "2023-06-30" @default.
• W4382502185 creator A5002098877 @default.
• W4382502185 creator A5012008098 @default.
• W4382502185 creator A5025660060 @default.
• W4382502185 creator A5035858548 @default.
• W4382502185 creator A5042161240 @default.
• W4382502185 creator A5042320429 @default.
• W4382502185 creator A5047098346 @default.
• W4382502185 creator A5055536407 @default.
• W4382502185 creator A5062169644 @default.
• W4382502185 creator A5063885814 @default.
• W4382502185 creator A5064622256 @default.
• W4382502185 creator A5066444153 @default.
• W4382502185 creator A5066750132 @default.
• W4382502185 creator A5070628952 @default.
• W4382502185 creator A5076252609 @default.
• W4382502185 creator A5082755854 @default.
• W4382502185 creator A5083438111 @default.
• W4382502185 creator A5084589887 @default.
• W4382502185 creator A5084907875 @default.
• W4382502185 date "2023-06-01" @default.
• W4382502185 modified "2023-10-15" @default.
• W4382502185 title "Pharmacological treatment of neuropsychiatric symptoms of dementia: a network meta-analysis" @default.
• W4382502185 cites W1555140172 @default.
• W4382502185 cites W1978663763 @default.
• W4382502185 cites W2010699829 @default.
• W4382502185 cites W2029821777 @default.
• W4382502185 cites W2030832792 @default.
• W4382502185 cites W2040557955 @default.
• W4382502185 cites W2048852891 @default.
• W4382502185 cites W2052223361 @default.
• W4382502185 cites W2058313277 @default.
• W4382502185 cites W2074147400 @default.
• W4382502185 cites W2075535893 @default.
• W4382502185 cites W2085805157 @default.
• W4382502185 cites W2091808438 @default.
• W4382502185 cites W2106963827 @default.
• W4382502185 cites W2108459440 @default.
• W4382502185 cites W2110207112 @default.
• W4382502185 cites W2111963393 @default.
• W4382502185 cites W2125776201 @default.
• W4382502185 cites W2132592055 @default.
• W4382502185 cites W2144625636 @default.
• W4382502185 cites W2144855317 @default.
• W4382502185 cites W2149515427 @default.
• W4382502185 cites W2156220037 @default.
• W4382502185 cites W2162034231 @default.
• W4382502185 cites W2314434775 @default.
• W4382502185 cites W2322295935 @default.
• W4382502185 cites W2414939357 @default.
• W4382502185 cites W2418813771 @default.
• W4382502185 cites W2517137788 @default.
• W4382502185 cites W2736307756 @default.
• W4382502185 cites W2797159220 @default.
• W4382502185 cites W2885957307 @default.
• W4382502185 cites W2900623060 @default.
• W4382502185 cites W2914055690 @default.
• W4382502185 cites W2914561915 @default.
• W4382502185 cites W2922909339 @default.
• W4382502185 cites W2957311488 @default.
• W4382502185 cites W2980849570 @default.
• W4382502185 cites W3037894709 @default.
• W4382502185 cites W3043989034 @default.
• W4382502185 cites W3138428632 @default.
• W4382502185 cites W3141256924 @default.
• W4382502185 doi "https://doi.org/10.1093/ageing/afad091" @default.
• W4382502185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37381843" @default.
• W4382502185 hasPublicationYear "2023" @default.
• W4382502185 type Work @default.
• W4382502185 citedByCount "1" @default.
• W4382502185 countsByYear W43825021852023 @default.
• W4382502185 crossrefType "journal-article" @default.
• W4382502185 hasAuthorship W4382502185A5002098877 @default.
• W4382502185 hasAuthorship W4382502185A5012008098 @default.
• W4382502185 hasAuthorship W4382502185A5025660060 @default.
• W4382502185 hasAuthorship W4382502185A5035858548 @default.
• W4382502185 hasAuthorship W4382502185A5042161240 @default.
• W4382502185 hasAuthorship W4382502185A5042320429 @default.
• W4382502185 hasAuthorship W4382502185A5047098346 @default.
• W4382502185 hasAuthorship W4382502185A5055536407 @default.
• W4382502185 hasAuthorship W4382502185A5062169644 @default.
• W4382502185 hasAuthorship W4382502185A5063885814 @default.
• W4382502185 hasAuthorship W4382502185A5064622256 @default.
• W4382502185 hasAuthorship W4382502185A5066444153 @default.
• W4382502185 hasAuthorship W4382502185A5066750132 @default.
• W4382502185 hasAuthorship W4382502185A5070628952 @default.
• W4382502185 hasAuthorship W4382502185A5076252609 @default.
• W4382502185 hasAuthorship W4382502185A5082755854 @default.
• W4382502185 hasAuthorship W4382502185A5083438111 @default.
• W4382502185 hasAuthorship W4382502185A5084589887 @default.
• W4382502185 hasAuthorship W4382502185A5084907875 @default.
• W4382502185 hasConcept C118552586 @default.
• W4382502185 hasConcept C126322002 @default.
• W4382502185 hasConcept C142724271 @default.
• W4382502185 hasConcept C156957248 @default.
• W4382502185 hasConcept C168563851 @default.
• W4382502185 hasConcept C17744445 @default.
• W4382502185 hasConcept C199539241 @default.
• W4382502185 hasConcept C204787440 @default.

• next