FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382502189> ?p ?o ?g. }

• W4382502189 endingPage "1509" @default.
• W4382502189 startingPage "1494" @default.
• W4382502189 abstract "BACKGROUND: MAGT1 (magnesium transporter 1) is a subunit of the oligosaccharide protein complex with thiol-disulfide oxidoreductase activity, supporting the process of N-glycosylation. MAGT1 deficiency was detected in human patients with X-linked immunodeficiency with magnesium defect syndrome and congenital disorders of glycosylation, resulting in decreased cation responses in lymphocytes, thereby inhibiting the immune response against viral infections. Curative hematopoietic stem cell transplantation of patients with X-linked immunodeficiency with magnesium defect causes fatal bleeding and thrombotic complications. METHODS: We studied the role of MAGT1 deficiency in platelet function in relation to arterial thrombosis and hemostasis using several in vitro experimental settings and in vivo models of arterial thrombosis and transient middle cerebral artery occlusion model of ischemic stroke. RESULTS: MAGT1-deficient mice ( Magt1 −/y ) displayed accelerated occlusive arterial thrombus formation in vivo, a shortened bleeding time, and profound brain damage upon focal cerebral ischemia. These defects resulted in increased calcium influx and enhanced second wave mediator release, which further reinforced platelet reactivity and aggregation responses. Supplementation of MgCl 2 or pharmacological blockade of TRPC6 (transient receptor potential cation channel, subfamily C, member 6) channel, but not inhibition of store-operated calcium entry, normalized the aggregation responses of Magt1 −/y platelets to the control level. GP (glycoprotein) VI activation of Magt1 −/y platelets resulted in hyperphosphorylation of Syk (spleen tyrosine kinase), LAT (linker for activation of T cells), and PLC (phospholipase C) γ2, whereas the inhibitory loop regulated by PKC (protein kinase C) was impaired. A hyperaggregation response to the GPVI agonist was confirmed in human platelets isolated from a MAGT1-deficient (X-linked immunodeficiency with magnesium defect) patient. Haploinsufficiency of TRPC6 in Magt1 −/y mice could normalize GPVI signaling, platelet aggregation, and thrombus formation in vivo. CONCLUSIONS: These results suggest that MAGT1 and TRPC6 are functionally linked. Therefore, deficiency or impaired functionality of MAGT1 could be a potential risk factor for arterial thrombosis and stroke." @default.
• W4382502189 created "2023-06-30" @default.
• W4382502189 creator A5001876942 @default.
• W4382502189 creator A5002335124 @default.
• W4382502189 creator A5002984465 @default.
• W4382502189 creator A5005418771 @default.
• W4382502189 creator A5008888080 @default.
• W4382502189 creator A5014366123 @default.
• W4382502189 creator A5016241725 @default.
• W4382502189 creator A5017831781 @default.
• W4382502189 creator A5020591780 @default.
• W4382502189 creator A5033161040 @default.
• W4382502189 creator A5045081364 @default.
• W4382502189 creator A5046814547 @default.
• W4382502189 creator A5056487867 @default.
• W4382502189 creator A5059354119 @default.
• W4382502189 creator A5064493858 @default.
• W4382502189 creator A5065854689 @default.
• W4382502189 creator A5068401442 @default.
• W4382502189 creator A5078018777 @default.
• W4382502189 creator A5079062707 @default.
• W4382502189 creator A5079584981 @default.
• W4382502189 creator A5087146117 @default.
• W4382502189 creator A5088033191 @default.
• W4382502189 date "2023-08-01" @default.
• W4382502189 modified "2023-10-18" @default.
• W4382502189 title "MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice" @default.
• W4382502189 cites W1525601872 @default.
• W4382502189 cites W170372288 @default.
• W4382502189 cites W1796574726 @default.
• W4382502189 cites W1823411753 @default.
• W4382502189 cites W1936450020 @default.
• W4382502189 cites W1971529415 @default.
• W4382502189 cites W1972429479 @default.
• W4382502189 cites W1976111921 @default.
• W4382502189 cites W1980652099 @default.
• W4382502189 cites W1982213737 @default.
• W4382502189 cites W2005876554 @default.
• W4382502189 cites W2005976556 @default.
• W4382502189 cites W2012002484 @default.
• W4382502189 cites W2017430753 @default.
• W4382502189 cites W2026640819 @default.
• W4382502189 cites W2026712108 @default.
• W4382502189 cites W2032570148 @default.
• W4382502189 cites W2045308957 @default.
• W4382502189 cites W2045565103 @default.
• W4382502189 cites W2046316489 @default.
• W4382502189 cites W2050102823 @default.
• W4382502189 cites W2051978340 @default.
• W4382502189 cites W2052090039 @default.
• W4382502189 cites W2056079625 @default.
• W4382502189 cites W2063093896 @default.
• W4382502189 cites W2063616047 @default.
• W4382502189 cites W2070860745 @default.
• W4382502189 cites W2072437147 @default.
• W4382502189 cites W2072793509 @default.
• W4382502189 cites W2091984207 @default.
• W4382502189 cites W2107123744 @default.
• W4382502189 cites W2111312140 @default.
• W4382502189 cites W2122553177 @default.
• W4382502189 cites W2122914556 @default.
• W4382502189 cites W2132733207 @default.
• W4382502189 cites W2133686229 @default.
• W4382502189 cites W2149924710 @default.
• W4382502189 cites W2152955882 @default.
• W4382502189 cites W2217514015 @default.
• W4382502189 cites W2313039228 @default.
• W4382502189 cites W2562416624 @default.
• W4382502189 cites W2789439796 @default.
• W4382502189 cites W2801190461 @default.
• W4382502189 cites W2887020136 @default.
• W4382502189 cites W2898295655 @default.
• W4382502189 cites W2901287937 @default.
• W4382502189 cites W2901813557 @default.
• W4382502189 cites W2917052447 @default.
• W4382502189 cites W2942872262 @default.
• W4382502189 cites W2953223404 @default.
• W4382502189 cites W2954714702 @default.
• W4382502189 cites W2962830754 @default.
• W4382502189 cites W2994954616 @default.
• W4382502189 cites W2996194594 @default.
• W4382502189 cites W3005664566 @default.
• W4382502189 cites W3047136650 @default.
• W4382502189 cites W4206100856 @default.
• W4382502189 cites W4213029195 @default.
• W4382502189 cites W4220658397 @default.
• W4382502189 cites W4247741685 @default.
• W4382502189 cites W4283361103 @default.
• W4382502189 cites W74395322 @default.
• W4382502189 doi "https://doi.org/10.1161/atvbaha.122.318115" @default.
• W4382502189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37381987" @default.
• W4382502189 hasPublicationYear "2023" @default.
• W4382502189 type Work @default.
• W4382502189 citedByCount "0" @default.
• W4382502189 crossrefType "journal-article" @default.
• W4382502189 hasAuthorship W4382502189A5001876942 @default.
• W4382502189 hasAuthorship W4382502189A5002335124 @default.
• W4382502189 hasAuthorship W4382502189A5002984465 @default.

• next