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- W4382502203 abstract "In the past, the treatment of IgA nephropathy (IgAN), which is the most common glomerulonephritis worldwide, mostly relied on blockade of the renin-angiotensin system as a central component of so-called supportive therapy as well as on high-dose systemic corticosteroid therapy.The supportive treatment arm has been expanded by the addition of sodium-glucose cotransporter-2 inhibitors, hydroxychloroquine, and, most recently, endothelin A receptor blockers. Treatment with high-dose systemic corticosteroids has become more controversial, with some studies observing no benefit and others documenting the protection of kidney function. However, all recent studies on systemic corticosteroids consistently found significant toxicity. An important novel approach to IgAN, therefore, is therapy with a targeted release formulation of budesonide with preferential release in the distal small intestine, given the mounting evidence for a gut-kidney axis in the pathophysiology of IgAN. In addition, emerging new therapeutic options include a variety of complement inhibitors as well as agents targeting B-cell proliferation and differentiation.In recent years, IgAN has become the focus of a considerable number of clinical studies that will significantly advance the development of new therapy strategies." @default.
- W4382502203 created "2023-06-30" @default.
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- W4382502203 date "2023-05-29" @default.
- W4382502203 modified "2023-10-12" @default.
- W4382502203 title "Novel agents for treating IgA nephropathy" @default.
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- W4382502203 doi "https://doi.org/10.1097/mnh.0000000000000902" @default.
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