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- W4382502302 abstract "Abstract Cryptococcus -associated immune reconstitution inflammatory syndrome (C-IRIS) is a condition frequently occurring in immunocompromised patients receiving antiretroviral therapy. C-IRIS patients exhibit many critical symptoms, including pulmonary distress, potentially complicating the progression and recovery from this condition. Here, utilizing our previously established mouse model of unmasking C-IRIS (CnH99 preinfection and adoptive transfer of CD4 + T cells), we demonstrated that pulmonary dysfunction associated with the C-IRIS condition in mice could be attributed to the infiltration of CD4 + T cells into the brain via the CCL8-CCR5 axis, which triggers the nucleus tractus solitarius (NTS) neuronal damage and neuronal disconnection via upregulated ephrin B3 and semaphorin 6B in CD4 + T cells. Our findings provide unique insight into the mechanism behind pulmonary dysfunction in C-IRIS and nominate potential therapeutic targets for treatment." @default.
- W4382502302 created "2023-06-30" @default.
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- W4382502302 date "2023-06-28" @default.
- W4382502302 modified "2023-10-16" @default.
- W4382502302 title "T cell infiltration into the brain triggers pulmonary dysfunction in murine Cryptococcus-associated IRIS" @default.
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- W4382502302 doi "https://doi.org/10.1038/s41467-023-39518-x" @default.
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- W4382502302 hasPublicationYear "2023" @default.
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