Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382502388> ?p ?o ?g. }
- W4382502388 abstract "Abstract An efficient and cost‐effective therapeutic vaccine is highly desirable for the prevention and treatment of cancer, which helps to strengthen the immune system and activate the T cell immune response. However, initiating such an adaptive immune response efficiently remains challenging, especially the deficient antigen presentation by dendritic cells (DCs) in the immunosuppressive tumor microenvironment. Herein, an efficient and dynamic antigen delivery system based on the magnetically actuated OVA‐CaCO 3 ‐SPIO robots (OCS‐robots) is rationally designed for active immunotherapy. Taking advantage of the unique dynamic features, the developed OCS‐robots achieve controllable motion capability under the rotating magnetic field. Specifically, with the active motion, the acid‐responsiveness of OCS‐robots is beneficial for the tumor acidity attenuating and lysosome escape as well as the subsequent antigen cross‐presentation of DCs. Furthermore, the dynamic OCS‐robots boost the crosstalk between the DCs and antigens, which displays prominent tumor immunotherapy effect on melanoma through cytotoxic T lymphocytes (CTLs). Such a strategy of dynamic vaccine delivery system enables the active activation of immune system based on the magnetically actuated OCS‐robots, which presents a plausible paradigm for incredibly efficient cancer immunotherapy by designing multifunctional and novel robot platforms in the future." @default.
- W4382502388 created "2023-06-30" @default.
- W4382502388 creator A5007520697 @default.
- W4382502388 creator A5007612582 @default.
- W4382502388 creator A5028957650 @default.
- W4382502388 creator A5034827616 @default.
- W4382502388 creator A5038751089 @default.
- W4382502388 creator A5038843080 @default.
- W4382502388 creator A5049264813 @default.
- W4382502388 creator A5051181056 @default.
- W4382502388 creator A5062963602 @default.
- W4382502388 creator A5071558335 @default.
- W4382502388 creator A5085536799 @default.
- W4382502388 creator A5087913698 @default.
- W4382502388 date "2023-06-29" @default.
- W4382502388 modified "2023-10-17" @default.
- W4382502388 title "Magnetically Actuated Biodegradable Nanorobots for Active Immunotherapy" @default.
- W4382502388 cites W1972141585 @default.
- W4382502388 cites W1980304178 @default.
- W4382502388 cites W1988727749 @default.
- W4382502388 cites W2025990308 @default.
- W4382502388 cites W2039233074 @default.
- W4382502388 cites W2051184702 @default.
- W4382502388 cites W2070658923 @default.
- W4382502388 cites W2087138396 @default.
- W4382502388 cites W2090433023 @default.
- W4382502388 cites W2134250807 @default.
- W4382502388 cites W2138103401 @default.
- W4382502388 cites W2154265087 @default.
- W4382502388 cites W2183528114 @default.
- W4382502388 cites W2234717249 @default.
- W4382502388 cites W2235523093 @default.
- W4382502388 cites W2265524865 @default.
- W4382502388 cites W2323579402 @default.
- W4382502388 cites W2327928095 @default.
- W4382502388 cites W2566310330 @default.
- W4382502388 cites W2768057701 @default.
- W4382502388 cites W2770449782 @default.
- W4382502388 cites W2771808227 @default.
- W4382502388 cites W2791822076 @default.
- W4382502388 cites W2883164386 @default.
- W4382502388 cites W2896542129 @default.
- W4382502388 cites W2903171611 @default.
- W4382502388 cites W2905662727 @default.
- W4382502388 cites W2917071227 @default.
- W4382502388 cites W2927281012 @default.
- W4382502388 cites W2940563858 @default.
- W4382502388 cites W2947789325 @default.
- W4382502388 cites W2954196095 @default.
- W4382502388 cites W2955952865 @default.
- W4382502388 cites W3007500699 @default.
- W4382502388 cites W3027787059 @default.
- W4382502388 cites W3032948918 @default.
- W4382502388 cites W3036221438 @default.
- W4382502388 cites W3107299086 @default.
- W4382502388 cites W3113111638 @default.
- W4382502388 cites W3116830667 @default.
- W4382502388 cites W3132105061 @default.
- W4382502388 cites W3134200710 @default.
- W4382502388 cites W3139297731 @default.
- W4382502388 cites W3144873095 @default.
- W4382502388 cites W3155285464 @default.
- W4382502388 cites W3186269042 @default.
- W4382502388 cites W3190743115 @default.
- W4382502388 cites W3198288249 @default.
- W4382502388 cites W3199462186 @default.
- W4382502388 cites W3206364759 @default.
- W4382502388 cites W3208038826 @default.
- W4382502388 cites W3213296011 @default.
- W4382502388 cites W4205131030 @default.
- W4382502388 cites W4205508460 @default.
- W4382502388 cites W4213317994 @default.
- W4382502388 cites W4234300672 @default.
- W4382502388 cites W4291493523 @default.
- W4382502388 cites W4376453986 @default.
- W4382502388 cites W4382502388 @default.
- W4382502388 doi "https://doi.org/10.1002/advs.202300540" @default.
- W4382502388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37382399" @default.
- W4382502388 hasPublicationYear "2023" @default.
- W4382502388 type Work @default.
- W4382502388 citedByCount "1" @default.
- W4382502388 countsByYear W43825023882023 @default.
- W4382502388 crossrefType "journal-article" @default.
- W4382502388 hasAuthorship W4382502388A5007520697 @default.
- W4382502388 hasAuthorship W4382502388A5007612582 @default.
- W4382502388 hasAuthorship W4382502388A5028957650 @default.
- W4382502388 hasAuthorship W4382502388A5034827616 @default.
- W4382502388 hasAuthorship W4382502388A5038751089 @default.
- W4382502388 hasAuthorship W4382502388A5038843080 @default.
- W4382502388 hasAuthorship W4382502388A5049264813 @default.
- W4382502388 hasAuthorship W4382502388A5051181056 @default.
- W4382502388 hasAuthorship W4382502388A5062963602 @default.
- W4382502388 hasAuthorship W4382502388A5071558335 @default.
- W4382502388 hasAuthorship W4382502388A5085536799 @default.
- W4382502388 hasAuthorship W4382502388A5087913698 @default.
- W4382502388 hasBestOaLocation W43825023881 @default.
- W4382502388 hasConcept C147483822 @default.
- W4382502388 hasConcept C154945302 @default.
- W4382502388 hasConcept C187911381 @default.
- W4382502388 hasConcept C203014093 @default.