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- W4382502813 abstract "Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting molecule MR1. The extent of MAIT TCR crossreactivity toward physiological, microbially unrelated antigens remains underexplored. We describe MAIT TCRs endowed with MR1-dependent reactivity to tumor and healthy cells in the absence of microbial metabolites. MAIT cells bearing TCRs crossreactive toward self are rare but commonly found within healthy donors and display T-helper-like functions in vitro. Experiments with MR1-tetramers loaded with distinct ligands revealed significant crossreactivity among MAIT TCRs both ex vivo and upon in vitro expansion. A canonical MAIT TCR was selected on the basis of extremely promiscuous MR1 recognition. Structural and molecular dynamic analyses associated promiscuity to unique TCRβ-chain features that were enriched within self-reactive MAIT cells of healthy individuals. Thus, self-reactive recognition of MR1 represents a functionally relevant indication of MAIT TCR crossreactivity, suggesting a potentially broader role of MAIT cells in immune homeostasis and diseases, beyond microbial immunosurveillance." @default.
- W4382502813 created "2023-06-30" @default.
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- W4382502813 date "2023-06-29" @default.
- W4382502813 modified "2023-09-27" @default.
- W4382502813 title "Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses" @default.
- W4382502813 cites W1536006864 @default.
- W4382502813 cites W1554262276 @default.
- W4382502813 cites W1919305622 @default.
- W4382502813 cites W1968844398 @default.
- W4382502813 cites W1968984443 @default.
- W4382502813 cites W1981700081 @default.
- W4382502813 cites W1995138538 @default.
- W4382502813 cites W1997222968 @default.
- W4382502813 cites W2008617601 @default.
- W4382502813 cites W2014275356 @default.
- W4382502813 cites W2016439640 @default.
- W4382502813 cites W2025795383 @default.
- W4382502813 cites W2030817385 @default.
- W4382502813 cites W2034273045 @default.
- W4382502813 cites W2044368289 @default.
- W4382502813 cites W2065252029 @default.
- W4382502813 cites W2066950435 @default.
- W4382502813 cites W2068767807 @default.
- W4382502813 cites W2073247934 @default.
- W4382502813 cites W2076524314 @default.
- W4382502813 cites W2081913102 @default.
- W4382502813 cites W2085117860 @default.
- W4382502813 cites W2089041106 @default.
- W4382502813 cites W2095719702 @default.
- W4382502813 cites W2101021136 @default.
- W4382502813 cites W2106582884 @default.
- W4382502813 cites W2108921801 @default.
- W4382502813 cites W2116117984 @default.
- W4382502813 cites W2117410945 @default.
- W4382502813 cites W2118515389 @default.
- W4382502813 cites W2124026197 @default.
- W4382502813 cites W2134764584 @default.
- W4382502813 cites W2139632459 @default.
- W4382502813 cites W2146074801 @default.
- W4382502813 cites W2147993766 @default.
- W4382502813 cites W2151505523 @default.
- W4382502813 cites W2154994578 @default.
- W4382502813 cites W2159211495 @default.
- W4382502813 cites W2160608319 @default.
- W4382502813 cites W2162709457 @default.
- W4382502813 cites W2163341755 @default.
- W4382502813 cites W2164271365 @default.
- W4382502813 cites W2164382089 @default.
- W4382502813 cites W2167029191 @default.
- W4382502813 cites W2171156871 @default.
- W4382502813 cites W2236872686 @default.
- W4382502813 cites W2323955433 @default.
- W4382502813 cites W2332712348 @default.
- W4382502813 cites W2404280981 @default.
- W4382502813 cites W2585341756 @default.
- W4382502813 cites W2586227194 @default.
- W4382502813 cites W2611663587 @default.
- W4382502813 cites W2714350637 @default.
- W4382502813 cites W2751895651 @default.
- W4382502813 cites W2765322245 @default.
- W4382502813 cites W2783729104 @default.
- W4382502813 cites W2790170256 @default.
- W4382502813 cites W2799927029 @default.
- W4382502813 cites W2802665011 @default.
- W4382502813 cites W2806770789 @default.
- W4382502813 cites W2883450285 @default.
- W4382502813 cites W2945685946 @default.
- W4382502813 cites W2949467224 @default.
- W4382502813 cites W2970506968 @default.
- W4382502813 cites W2970705750 @default.