Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382517085> ?p ?o ?g. }
- W4382517085 abstract "Abstract Background Gastric adenocarcinomas are a leading cause of global mortality, associated with chronic infection with Helicobacter pylori . The mechanisms by which infection with H. pylori contributes to carcinogenesis are not well understood. Recent studies from subjects with and without gastric cancer have identified significant DNA methylation alterations in normal gastric mucosa associated with H. pylori infection and gastric cancer risk. Here we further investigated DNA methylation alterations in normal gastric mucosa in gastric cancer cases (n = 42) and control subjects (n = 42) with H. pylori infection data. We assessed tissue cell type composition, DNA methylation alterations within cell populations, epigenetic aging, and repetitive element methylation. Results In normal gastric mucosa of both gastric cancer cases and control subjects, we observed increased epigenetic age acceleration associated with H. pylori infection. We also observed an increased mitotic tick rate associated with H. pylori infection in both gastric cancer cases and controls. Significant differences in immune cell populations associated with H. pylori infection in normal tissue from cancer cases and controls were identified using DNA methylation cell type deconvolution. We also found natural killer cell-specific methylation alterations in normal mucosa from gastric cancer patients with H. pylori infection. Conclusions Our findings from normal gastric mucosa provide insight into underlying cellular composition and epigenetic aspects of H. pylori associated gastric cancer etiology." @default.
- W4382517085 created "2023-06-30" @default.
- W4382517085 creator A5061392598 @default.
- W4382517085 creator A5081393377 @default.
- W4382517085 creator A5082545896 @default.
- W4382517085 date "2023-06-29" @default.
- W4382517085 modified "2023-09-26" @default.
- W4382517085 title "Normal gastric tissue<i>Helicobacter pylori</i>infection is associated with epigenetic age acceleration, increased mitotic tick rate, tissue cell composition, and Natural Killer cell methylation alterations" @default.
- W4382517085 cites W1465453806 @default.
- W4382517085 cites W1530235393 @default.
- W4382517085 cites W1895813995 @default.
- W4382517085 cites W1955052620 @default.
- W4382517085 cites W1974047233 @default.
- W4382517085 cites W1975138647 @default.
- W4382517085 cites W1979585972 @default.
- W4382517085 cites W1997270596 @default.
- W4382517085 cites W2004078197 @default.
- W4382517085 cites W2019078072 @default.
- W4382517085 cites W2019137217 @default.
- W4382517085 cites W2024819383 @default.
- W4382517085 cites W2045770684 @default.
- W4382517085 cites W2064164822 @default.
- W4382517085 cites W2068351971 @default.
- W4382517085 cites W2078497756 @default.
- W4382517085 cites W2109754318 @default.
- W4382517085 cites W2121091193 @default.
- W4382517085 cites W2127431419 @default.
- W4382517085 cites W2127810485 @default.
- W4382517085 cites W2146512944 @default.
- W4382517085 cites W2165806252 @default.
- W4382517085 cites W2169065633 @default.
- W4382517085 cites W2537310520 @default.
- W4382517085 cites W2732950170 @default.
- W4382517085 cites W2789337193 @default.
- W4382517085 cites W2805049578 @default.
- W4382517085 cites W2896674942 @default.
- W4382517085 cites W2903374927 @default.
- W4382517085 cites W2911456342 @default.
- W4382517085 cites W2919386822 @default.
- W4382517085 cites W2949023387 @default.
- W4382517085 cites W2949100461 @default.
- W4382517085 cites W2972333913 @default.
- W4382517085 cites W2981358775 @default.
- W4382517085 cites W2989996227 @default.
- W4382517085 cites W2995331318 @default.
- W4382517085 cites W3037887056 @default.
- W4382517085 cites W3084665876 @default.
- W4382517085 cites W3124225662 @default.
- W4382517085 cites W3128646645 @default.
- W4382517085 cites W3137514798 @default.
- W4382517085 cites W3165106304 @default.
- W4382517085 cites W3168958685 @default.
- W4382517085 doi "https://doi.org/10.1101/2023.06.28.546926" @default.
- W4382517085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37425894" @default.
- W4382517085 hasPublicationYear "2023" @default.
- W4382517085 type Work @default.
- W4382517085 citedByCount "0" @default.
- W4382517085 crossrefType "posted-content" @default.
- W4382517085 hasAuthorship W4382517085A5061392598 @default.
- W4382517085 hasAuthorship W4382517085A5081393377 @default.
- W4382517085 hasAuthorship W4382517085A5082545896 @default.
- W4382517085 hasBestOaLocation W43825170851 @default.
- W4382517085 hasConcept C104317684 @default.
- W4382517085 hasConcept C121608353 @default.
- W4382517085 hasConcept C142724271 @default.
- W4382517085 hasConcept C150194340 @default.
- W4382517085 hasConcept C190727270 @default.
- W4382517085 hasConcept C203014093 @default.
- W4382517085 hasConcept C2776409635 @default.
- W4382517085 hasConcept C2779422922 @default.
- W4382517085 hasConcept C2781443798 @default.
- W4382517085 hasConcept C33288867 @default.
- W4382517085 hasConcept C41091548 @default.
- W4382517085 hasConcept C502942594 @default.
- W4382517085 hasConcept C54355233 @default.
- W4382517085 hasConcept C552990157 @default.
- W4382517085 hasConcept C55493867 @default.
- W4382517085 hasConcept C555283112 @default.
- W4382517085 hasConcept C71924100 @default.
- W4382517085 hasConcept C86803240 @default.
- W4382517085 hasConceptScore W4382517085C104317684 @default.
- W4382517085 hasConceptScore W4382517085C121608353 @default.
- W4382517085 hasConceptScore W4382517085C142724271 @default.
- W4382517085 hasConceptScore W4382517085C150194340 @default.
- W4382517085 hasConceptScore W4382517085C190727270 @default.
- W4382517085 hasConceptScore W4382517085C203014093 @default.
- W4382517085 hasConceptScore W4382517085C2776409635 @default.
- W4382517085 hasConceptScore W4382517085C2779422922 @default.
- W4382517085 hasConceptScore W4382517085C2781443798 @default.
- W4382517085 hasConceptScore W4382517085C33288867 @default.
- W4382517085 hasConceptScore W4382517085C41091548 @default.
- W4382517085 hasConceptScore W4382517085C502942594 @default.
- W4382517085 hasConceptScore W4382517085C54355233 @default.
- W4382517085 hasConceptScore W4382517085C552990157 @default.
- W4382517085 hasConceptScore W4382517085C55493867 @default.
- W4382517085 hasConceptScore W4382517085C555283112 @default.
- W4382517085 hasConceptScore W4382517085C71924100 @default.
- W4382517085 hasConceptScore W4382517085C86803240 @default.
- W4382517085 hasLocation W43825170851 @default.
- W4382517085 hasLocation W43825170852 @default.