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• W4382519093 abstract "Vitis vinifera Egyptian edible leaf extract loaded on a soybean lecithin, cholesterol, and Carbopol gel preparation (VVL-liposomal gel) was prepared to maximize the in vivo wound healing and anti-MRSA activities for the crude extract, using an excision wound model and focusing on TLR-2, MCP-1, CXCL-1, CXCL-2, IL-6 and IL-1β, and MRSA (wound infection model, and peritonitis infection model). VVL-liposomal gel was stable with significant drug entrapment efficiency reaching 88% ± 3, zeta potential value ranging from -50 to -63, and a size range of 50-200 μm nm in diameter. The in vivo evaluation proved the ability of VVL-liposomal gel to gradually release the drugs in a sustained manner with greater complete wound healing effect and tissue repair after 7 days of administration, with a significant decrease in bacterial count compared with the crude extract. Phytochemical investigation of the crude extract of the leaves yielded fourteen compounds: two new stilbenes (1, 2), along with twelve known ones (3-14). Furthermore, a computational study was conducted to identify the genes and possible pathways responsible for the anti-MRSA activity of the isolated compounds, and inverse docking was used to identify the most likely molecular targets that could mediate the extract's antibacterial activity. Gyr-B was discovered to be the best target for compounds 1 and 2. Hence, VVL-liposomal gel can be used as a novel anti-dermatophytic agent with potent wound healing and anti-MRSA capacity, paving the way for future clinical research." @default.
• W4382519093 created "2023-06-30" @default.
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• W4382519093 date "2023-01-01" @default.
• W4382519093 modified "2023-10-18" @default.
• W4382519093 title "<i>Vitis vinifera</i> leaf extract liposomal Carbopol gel preparation's potential wound healing and antibacterial benefits: <i>in vivo</i>, phytochemical, and computational investigation" @default.
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• W4382519093 doi "https://doi.org/10.1039/d2fo03212k" @default.
• W4382519093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37462414" @default.

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