FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382568229> ?p ?o ?g. }

• W4382568229 abstract "<sec> <title>BACKGROUND</title> Digital therapeutic care (DTC) programs are unsupervised app-based treatments that provide video exercises and educational material to patients with nonspecific low back pain during episodes of pain and functional disability. German statutory health insurance can reimburse DTC programs since 2019, but evidence on efficacy and reasonable pricing remains scarce. This paper presents a probabilistic sensitivity analysis (PSA) to evaluate the efficacy and cost-utility of a DTC app against treatment as usual (TAU) in Germany. </sec> <sec> <title>OBJECTIVE</title> The aim of this study was to perform a PSA in the form of a Monte Carlo simulation based on the deterministic base case analysis to account for model assumptions and parameter uncertainty. We also intend to explore to what extent the results in this probabilistic analysis differ from the results in the base case analysis and to what extent a shortage of outcome data concerning quality-of-life (QoL) metrics impacts the overall results. </sec> <sec> <title>METHODS</title> The PSA builds upon a state-transition Markov chain with a 4-week cycle length over a model time horizon of 3 years from a recently published deterministic cost-utility analysis. A Monte Carlo simulation with 10,000 iterations and a cohort size of 10,000 was employed to evaluate the cost-utility from a societal perspective. Quality-adjusted life years (QALYs) were derived from Veterans RAND 6-Dimension (VR-6D) and Short-Form 6-Dimension (SF-6D) single utility scores. Finally, we also simulated reducing the price for a 3-month app prescription to analyze at which price threshold DTC would result in being the dominant strategy over TAU in Germany. </sec> <sec> <title>RESULTS</title> The Monte Carlo simulation yielded on average a €135.97 (a currency exchange rate of EUR €1=US $1.069 is applicable) incremental cost and 0.004 incremental QALYs per person and year for the unsupervised DTC app strategy compared to in-person physiotherapy in Germany. The corresponding incremental cost-utility ratio (ICUR) amounts to an additional €34,315.19 per additional QALY. DTC yielded more QALYs in 54.96% of the iterations. DTC dominates TAU in 24.04% of the iterations for QALYs. Reducing the app price in the simulation from currently €239.96 to €164.61 for a 3-month prescription could yield a negative ICUR and thus make DTC the dominant strategy, even though the estimated probability of DTC being more effective than TAU is only 54.96%. </sec> <sec> <title>CONCLUSIONS</title> Decision-makers should be cautious when considering the reimbursement of DTC apps since no significant treatment effect was found, and the probability of cost-effectiveness remains below 60% even for an infinite willingness-to-pay threshold. More app-based studies involving the utilization of QoL outcome parameters are urgently needed to account for the low and limited precision of the available QoL input parameters, which are crucial to making profound recommendations concerning the cost-utility of novel apps. </sec>" @default.
• W4382568229 created "2023-06-30" @default.
• W4382568229 creator A5023759058 @default.
• W4382568229 creator A5071606253 @default.
• W4382568229 creator A5073437309 @default.
• W4382568229 date "2022-11-25" @default.
• W4382568229 modified "2023-09-27" @default.
• W4382568229 title "Economic Evaluation of Digital Therapeutic Care Apps for Unsupervised Treatment of Low Back Pain: Monte Carlo Simulation (Preprint)" @default.
• W4382568229 cites W1977849332 @default.
• W4382568229 cites W2011536372 @default.
• W4382568229 cites W2066017863 @default.
• W4382568229 cites W2077151163 @default.
• W4382568229 cites W2077913849 @default.
• W4382568229 cites W2115308689 @default.
• W4382568229 cites W2136633491 @default.
• W4382568229 cites W2167810128 @default.
• W4382568229 cites W2618889646 @default.
• W4382568229 cites W2801155169 @default.
• W4382568229 cites W2811473826 @default.
• W4382568229 cites W2943409625 @default.
• W4382568229 cites W2944192529 @default.
• W4382568229 cites W2944899930 @default.
• W4382568229 cites W3033133316 @default.
• W4382568229 cites W3041856132 @default.
• W4382568229 cites W3216409176 @default.
• W4382568229 cites W4205969091 @default.
• W4382568229 cites W4210909635 @default.
• W4382568229 doi "https://doi.org/10.2196/preprints.44585" @default.
• W4382568229 hasPublicationYear "2022" @default.
• W4382568229 type Work @default.
• W4382568229 citedByCount "0" @default.
• W4382568229 crossrefType "posted-content" @default.
• W4382568229 hasAuthorship W4382568229A5023759058 @default.
• W4382568229 hasAuthorship W4382568229A5071606253 @default.
• W4382568229 hasAuthorship W4382568229A5073437309 @default.
• W4382568229 hasConcept C105795698 @default.
• W4382568229 hasConcept C107673813 @default.
• W4382568229 hasConcept C111350023 @default.
• W4382568229 hasConcept C149782125 @default.
• W4382568229 hasConcept C154945302 @default.
• W4382568229 hasConcept C162118730 @default.
• W4382568229 hasConcept C162324750 @default.
• W4382568229 hasConcept C19499675 @default.
• W4382568229 hasConcept C202444582 @default.
• W4382568229 hasConcept C33676613 @default.
• W4382568229 hasConcept C33923547 @default.
• W4382568229 hasConcept C41008148 @default.
• W4382568229 hasConcept C49937458 @default.
• W4382568229 hasConcept C71924100 @default.
• W4382568229 hasConceptScore W4382568229C105795698 @default.
• W4382568229 hasConceptScore W4382568229C107673813 @default.
• W4382568229 hasConceptScore W4382568229C111350023 @default.
• W4382568229 hasConceptScore W4382568229C149782125 @default.
• W4382568229 hasConceptScore W4382568229C154945302 @default.
• W4382568229 hasConceptScore W4382568229C162118730 @default.
• W4382568229 hasConceptScore W4382568229C162324750 @default.
• W4382568229 hasConceptScore W4382568229C19499675 @default.
• W4382568229 hasConceptScore W4382568229C202444582 @default.
• W4382568229 hasConceptScore W4382568229C33676613 @default.
• W4382568229 hasConceptScore W4382568229C33923547 @default.
• W4382568229 hasConceptScore W4382568229C41008148 @default.
• W4382568229 hasConceptScore W4382568229C49937458 @default.
• W4382568229 hasConceptScore W4382568229C71924100 @default.
• W4382568229 hasLocation W43825682291 @default.
• W4382568229 hasOpenAccess W4382568229 @default.
• W4382568229 hasPrimaryLocation W43825682291 @default.
• W4382568229 hasRelatedWork W2040790268 @default.
• W4382568229 hasRelatedWork W2047834101 @default.
• W4382568229 hasRelatedWork W2290228402 @default.
• W4382568229 hasRelatedWork W2592308920 @default.
• W4382568229 hasRelatedWork W2748952813 @default.
• W4382568229 hasRelatedWork W2763788391 @default.
• W4382568229 hasRelatedWork W2899084033 @default.
• W4382568229 hasRelatedWork W2948895238 @default.
• W4382568229 hasRelatedWork W3190715739 @default.
• W4382568229 hasRelatedWork W4290792893 @default.
• W4382568229 isParatext "false" @default.
• W4382568229 isRetracted "false" @default.
• W4382568229 workType "article" @default.