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- W4382581915 abstract "This work had as main objective to encapsulate vitamin D3 (VD3) into nanostructured lipid carriers (NLCs) using rhamnolipids as surfactant. Glycerol monostearate and medium chain triglycerides with 2.625 % of VD3 were used as lipid materials. The three formulations of NLCs with VD3 (NLCs + VD3) were composed by 99 % of aqueous phase, 1 % of lipid phase and 0.05 % of surfactant. The difference between them was the ratio of solid:liquid in lipid phase. The NLCs + VD3 sizes ranged between 92.1 and 108.1 nm. The most stable formulation maintaining their caracteristics for 60 days at 4 °C. The NLCs + VD3 cytotoxicity demonstrated that concentrations of 0.25 mg/mL or lower up had a good biocompatibility in vitro. During the in vitro digestion, formulations with lower sizes and higher content on solid lipid had higher lipolysis rate and consequently higher VD3 bioaccessibility. The rhamnolipids-based NLCs are a good option for the encapsulation of VD3." @default.
- W4382581915 created "2023-06-30" @default.
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- W4382581915 date "2023-11-01" @default.
- W4382581915 modified "2023-10-18" @default.
- W4382581915 title "Encapsulation of vitamin D3 using rhamnolipids-based nanostructured lipid carriers" @default.
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- W4382581915 doi "https://doi.org/10.1016/j.foodchem.2023.136654" @default.
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