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• W4382583952 abstract "The development of an electrochemical detection of amyloid beta (Aβ) (1-40) peptides as a bio marker of Alzheimer’s disease (AD) was carried out on a Pt disk microelectrode. The electrode was modified with poly-ortho- Phenylenediamine (PPD) and mouse monoclonal beta amyloid antibody (mAβA) was immobilized to form Pt/PPD/mAβA immunosensor. The measurements were done in Phosphate Buffer Solution (PBS) by applying Electrochemical Impedance Spectroscopy (EIS) technique. The detection is evaluated by the changes in the Nyquist spectra and values of charge transfer resistance (Rct) that were extracted from a modified Randles equivalent circuit. A semi-circle Nyquist plot was observed in the presence of Aβ (1-40) whereas a linear spectra were exhibited in the absence of Aβ (1-40). In addition, as the concentrations of Aβ (1-40) solution increased, the diameter of Nyquist plots was also increased. Surface morphology of Aβ (1-40) adsorbed on microelectrode was observed using Field-emission Scanning Electron Microscope (FESEM) and Optical Microscopic. Based on these findings, a promising in vivo immunosensor for Aβ (1 -40) detection that can be used as an alternative in monitoring inhibitors of Aβ (1-40) aggregation research." @default.
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• W4382583952 date "2016-01-01" @default.
• W4382583952 modified "2023-10-05" @default.
• W4382583952 title "Development of Impedimetric Immunosensor for The Detection of Amyloid Beta (1- 40) on maβa/ortho-Polyphenylenediamine Modified Platinum Micro Disk Electrode" @default.
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• W4382583952 doi "https://doi.org/10.1016/s1452-3981(23)15890-1" @default.
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