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• W4382599529 endingPage "5081" @default.
• W4382599529 startingPage "5081" @default.
• W4382599529 abstract "Chemoprevention is one of the ways to fight colorectal cancer, which is a huge challenge in oncology. Numerous pieces of evidence indicate that chronic inflammation in the course of Crohn’s disease or ulcerative colitis (UC) is a significant cancer risk factor. Epidemiologic studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), including mesalazine, has beneficial effects on colitis-associated colorectal cancer. Mesalazine is a first-line therapy for UC and is also widely used for maintaining remission in UC. Data showed that mesalazine has antiproliferative properties associated with cyclooxygenase (COX) inhibition but can also act through COX-independent pathways. This review summarizes knowledge about mesalazine’s molecular mechanisms of action and chemopreventive effect by which it could interfere with colorectal cancer cell proliferation and survival." @default.
• W4382599529 created "2023-06-30" @default.
• W4382599529 creator A5039824494 @default.
• W4382599529 creator A5040765628 @default.
• W4382599529 creator A5056640420 @default.
• W4382599529 date "2023-06-29" @default.
• W4382599529 modified "2023-10-14" @default.
• W4382599529 title "Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer" @default.
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