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- W4382599669 startingPage "1746" @default.
- W4382599669 abstract "Mechanotransduction is a molecular process by which cells translate physical stimuli exerted by the external environment into biochemical pathways to orchestrate the cellular shape and function. Even with the advancements in the field, the molecular events leading to the signal cascade are still unclear. The current biotechnology of tissue engineering offers the opportunity to study in vitro the effect of the physical stimuli exerted by biomaterial on stem cells and the mechanotransduction pathway involved in the process. Here, we cultured multipotent human mesenchymal/stromal cells (hMSCs) isolated from bone marrow (hBM-MSCs) and adipose tissue (hASCs) on films of poly(butylene 1,4-cyclohexane dicarboxylate) (PBCE) and a PBCE-based copolymer containing 50 mol% of butylene diglycolate co-units (BDG50), to intentionally tune the surface hydrophilicity and the stiffness (PBCE = 560 Mpa; BDG50 = 94 MPa). We demonstrated the activated distinctive mechanotransduction pathways, resulting in the acquisition of an elongated shape in hBM-MSCs on the BDG50 film and in maintaining the canonical morphology on the PBCE film. Notably, hASCs acquired a new, elongated morphology on both the PBCE and BDG50 films. We found that these events were mainly due to the differences in the expression of Cofilin1, Vimentin, Filamin A, and Talin, which established highly sensitive machinery by which, rather than hASCs, hBM-MSCs distinguished PBCE from BDG50 films." @default.
- W4382599669 created "2023-06-30" @default.
- W4382599669 creator A5019188777 @default.
- W4382599669 creator A5028353996 @default.
- W4382599669 creator A5044906308 @default.
- W4382599669 creator A5086242623 @default.
- W4382599669 creator A5088196352 @default.
- W4382599669 creator A5089481787 @default.
- W4382599669 date "2023-06-29" @default.
- W4382599669 modified "2023-09-25" @default.
- W4382599669 title "Tight Regulation of Mechanotransducer Proteins Distinguishes the Response of Adult Multipotent Mesenchymal Cells on PBCE-Derivative Polymer Films with Different Hydrophilicity and Stiffness" @default.
- W4382599669 cites W1862989971 @default.
- W4382599669 cites W1967669223 @default.
- W4382599669 cites W1972228155 @default.
- W4382599669 cites W1980350663 @default.
- W4382599669 cites W1994566149 @default.
- W4382599669 cites W2000039248 @default.
- W4382599669 cites W2001973848 @default.
- W4382599669 cites W2018512891 @default.
- W4382599669 cites W2025371271 @default.
- W4382599669 cites W2044895919 @default.
- W4382599669 cites W2046688092 @default.
- W4382599669 cites W2047696477 @default.
- W4382599669 cites W2048305477 @default.
- W4382599669 cites W2055601386 @default.
- W4382599669 cites W2061167130 @default.
- W4382599669 cites W2118292762 @default.
- W4382599669 cites W2126048177 @default.
- W4382599669 cites W2128157572 @default.
- W4382599669 cites W2132546029 @default.
- W4382599669 cites W2136097990 @default.
- W4382599669 cites W2146337514 @default.
- W4382599669 cites W2149873896 @default.
- W4382599669 cites W2162911482 @default.
- W4382599669 cites W2163567894 @default.
- W4382599669 cites W2167279371 @default.
- W4382599669 cites W2184157606 @default.
- W4382599669 cites W2188169307 @default.
- W4382599669 cites W2257474288 @default.
- W4382599669 cites W2279353265 @default.
- W4382599669 cites W2319543806 @default.
- W4382599669 cites W2321409881 @default.
- W4382599669 cites W2346331532 @default.
- W4382599669 cites W2594954404 @default.
- W4382599669 cites W2747319570 @default.
- W4382599669 cites W2749319116 @default.
- W4382599669 cites W2752494835 @default.
- W4382599669 cites W2755452354 @default.
- W4382599669 cites W2758838459 @default.
- W4382599669 cites W2767569544 @default.
- W4382599669 cites W2768731424 @default.
- W4382599669 cites W2787362694 @default.
- W4382599669 cites W2800497993 @default.
- W4382599669 cites W2802195803 @default.
- W4382599669 cites W2820932019 @default.
- W4382599669 cites W2888648939 @default.
- W4382599669 cites W2889530976 @default.
- W4382599669 cites W2896693136 @default.
- W4382599669 cites W2899756959 @default.
- W4382599669 cites W2912067199 @default.
- W4382599669 cites W2942273685 @default.
- W4382599669 cites W2944786872 @default.
- W4382599669 cites W2947612558 @default.
- W4382599669 cites W2954135312 @default.
- W4382599669 cites W2956745804 @default.
- W4382599669 cites W2965783660 @default.
- W4382599669 cites W2973068260 @default.
- W4382599669 cites W2981899793 @default.
- W4382599669 cites W2990811783 @default.
- W4382599669 cites W2990978095 @default.
- W4382599669 cites W2998253243 @default.
- W4382599669 cites W2999405113 @default.
- W4382599669 cites W3003751606 @default.
- W4382599669 cites W3004487585 @default.
- W4382599669 cites W3005179877 @default.
- W4382599669 cites W3038302278 @default.
- W4382599669 cites W3097792438 @default.
- W4382599669 cites W3098597306 @default.
- W4382599669 cites W3106767114 @default.
- W4382599669 cites W3107665742 @default.
- W4382599669 cites W3111857441 @default.
- W4382599669 cites W3136725363 @default.
- W4382599669 cites W3137625083 @default.
- W4382599669 cites W3165286686 @default.
- W4382599669 cites W3166556984 @default.
- W4382599669 cites W3193299269 @default.
- W4382599669 cites W3202936169 @default.
- W4382599669 cites W3207333598 @default.
- W4382599669 cites W3213002095 @default.
- W4382599669 cites W4206817746 @default.
- W4382599669 cites W4212944020 @default.
- W4382599669 cites W4223578690 @default.
- W4382599669 cites W4224254234 @default.
- W4382599669 cites W4225264764 @default.
- W4382599669 cites W4250821200 @default.
- W4382599669 cites W4251432945 @default.
- W4382599669 cites W4291178543 @default.
- W4382599669 cites W4292486126 @default.