Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382600443> ?p ?o ?g. }
- W4382600443 endingPage "e200139" @default.
- W4382600443 startingPage "e200139" @default.
- W4382600443 abstract "The therapeutic success and widespread approval of genetically engineered T cells for a variety of hematologic malignancies spurred the development of synthetic cell-based immunotherapies for CNS lymphoma, primary brain tumors, and a growing spectrum of nononcologic disease conditions of the nervous system. Chimeric antigen receptor effector T cells bear the potential to deplete target cells with higher efficacy, better tissue penetration, and greater depth than antibody-based cell depletion therapies. In multiple sclerosis and other autoimmune disorders, engineered T-cell therapies are being designed and currently tested in clinical trials for their safety and efficacy to eliminate pathogenic B-lineage cells. Chimeric autoantibody receptor T cells expressing a disease-relevant autoantigen as cell surface domains are designed to selectively deplete autoreactive B cells. Alternative to cell depletion, synthetic antigen-specific regulatory T cells can be engineered to locally restrain inflammation, support immune tolerance, or efficiently deliver neuroprotective factors in brain diseases in which current therapeutic options are very limited. In this article, we illustrate prospects and bottlenecks for the clinical development and implementation of engineered cellular immunotherapies in neurologic diseases." @default.
- W4382600443 created "2023-06-30" @default.
- W4382600443 creator A5015324959 @default.
- W4382600443 creator A5024611239 @default.
- W4382600443 creator A5042628274 @default.
- W4382600443 date "2023-06-29" @default.
- W4382600443 modified "2023-09-23" @default.
- W4382600443 title "Synthetic Cell-Based Immunotherapies for Neurologic Diseases" @default.
- W4382600443 cites W1547955534 @default.
- W4382600443 cites W1581336840 @default.
- W4382600443 cites W1619537825 @default.
- W4382600443 cites W1693283493 @default.
- W4382600443 cites W1977238516 @default.
- W4382600443 cites W2030017878 @default.
- W4382600443 cites W2054504604 @default.
- W4382600443 cites W2094652659 @default.
- W4382600443 cites W2106083290 @default.
- W4382600443 cites W2135280067 @default.
- W4382600443 cites W2158202057 @default.
- W4382600443 cites W2163137692 @default.
- W4382600443 cites W2473078810 @default.
- W4382600443 cites W2481298264 @default.
- W4382600443 cites W2504729294 @default.
- W4382600443 cites W2542427033 @default.
- W4382600443 cites W2561881161 @default.
- W4382600443 cites W2563656670 @default.
- W4382600443 cites W2567424265 @default.
- W4382600443 cites W2583613336 @default.
- W4382600443 cites W2604982880 @default.
- W4382600443 cites W2605626471 @default.
- W4382600443 cites W2607356458 @default.
- W4382600443 cites W2738678436 @default.
- W4382600443 cites W2778172184 @default.
- W4382600443 cites W2787578932 @default.
- W4382600443 cites W2789903110 @default.
- W4382600443 cites W2889295047 @default.
- W4382600443 cites W2913136103 @default.
- W4382600443 cites W2918633605 @default.
- W4382600443 cites W2978587517 @default.
- W4382600443 cites W2981958753 @default.
- W4382600443 cites W3004467467 @default.
- W4382600443 cites W3040292335 @default.
- W4382600443 cites W3081379129 @default.
- W4382600443 cites W3113431027 @default.
- W4382600443 cites W3123632399 @default.
- W4382600443 cites W3135686814 @default.
- W4382600443 cites W3157520262 @default.
- W4382600443 cites W3160217129 @default.
- W4382600443 cites W3162374648 @default.
- W4382600443 cites W3163657510 @default.
- W4382600443 cites W3178970276 @default.
- W4382600443 cites W3196726943 @default.
- W4382600443 cites W4200160797 @default.
- W4382600443 cites W4206278071 @default.
- W4382600443 cites W4206401256 @default.
- W4382600443 cites W4207068215 @default.
- W4382600443 cites W4210924686 @default.
- W4382600443 cites W4213165752 @default.
- W4382600443 cites W4223502732 @default.
- W4382600443 cites W4224293261 @default.
- W4382600443 cites W4226265944 @default.
- W4382600443 cites W4293439694 @default.
- W4382600443 cites W4295271042 @default.
- W4382600443 cites W4295929648 @default.
- W4382600443 cites W4297120084 @default.
- W4382600443 cites W4303453674 @default.
- W4382600443 cites W4317467383 @default.
- W4382600443 cites W4321480081 @default.
- W4382600443 doi "https://doi.org/10.1212/nxi.0000000000200139" @default.
- W4382600443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37385738" @default.
- W4382600443 hasPublicationYear "2023" @default.
- W4382600443 type Work @default.
- W4382600443 citedByCount "0" @default.
- W4382600443 crossrefType "journal-article" @default.
- W4382600443 hasAuthorship W4382600443A5015324959 @default.
- W4382600443 hasAuthorship W4382600443A5024611239 @default.
- W4382600443 hasAuthorship W4382600443A5042628274 @default.
- W4382600443 hasBestOaLocation W43826004431 @default.
- W4382600443 hasConcept C10882517 @default.
- W4382600443 hasConcept C147483822 @default.
- W4382600443 hasConcept C1491633281 @default.
- W4382600443 hasConcept C203014093 @default.
- W4382600443 hasConcept C2777701055 @default.
- W4382600443 hasConcept C2780130043 @default.
- W4382600443 hasConcept C2780640218 @default.
- W4382600443 hasConcept C3875195 @default.
- W4382600443 hasConcept C502942594 @default.
- W4382600443 hasConcept C54355233 @default.
- W4382600443 hasConcept C71924100 @default.
- W4382600443 hasConcept C86803240 @default.
- W4382600443 hasConcept C8891405 @default.
- W4382600443 hasConceptScore W4382600443C10882517 @default.
- W4382600443 hasConceptScore W4382600443C147483822 @default.
- W4382600443 hasConceptScore W4382600443C1491633281 @default.
- W4382600443 hasConceptScore W4382600443C203014093 @default.
- W4382600443 hasConceptScore W4382600443C2777701055 @default.
- W4382600443 hasConceptScore W4382600443C2780130043 @default.
- W4382600443 hasConceptScore W4382600443C2780640218 @default.