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- W4382630987 abstract "Selective autophagy is a double-edged sword in antiviral immunity and regulated by various autophagy receptors. However, it remains unclear how to balance the opposite roles by one autophagy receptor. We previously identified a virus-induced small peptide called VISP1 as a selective autophagy receptor that facilitates virus infections by targeting components of antiviral RNA silencing. However, we show here that VISP1 can also inhibit virus infections by mediating autophagic degradation of viral suppressors of RNA silencing (VSRs). VISP1 targets the cucumber mosaic virus (CMV) 2b protein for degradation and attenuates its suppression activity on RNA silencing. Knockout and overexpression of VISP1 exhibit compromised and enhanced resistance against late infection of CMV, respectively. Consequently, VISP1 induces symptom recovery from CMV infection by triggering 2b turnover. VISP1 also targets the C2/AC2 VSRs of two geminiviruses and enhances antiviral immunity. Together, VISP1 induces symptom recovery from severe infections of plant viruses through controlling VSR accumulation." @default.
- W4382630987 created "2023-07-01" @default.
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- W4382630987 date "2023-06-29" @default.
- W4382630987 modified "2023-10-16" @default.
- W4382630987 title "A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors" @default.
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- W4382630987 doi "https://doi.org/10.1038/s41467-023-39426-0" @default.
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