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- W4382631336 abstract "Migrating cell collectives navigate complex tissue environments both during normal development and in pathological contexts such as tumor invasion and metastasis. To do this, cells in collectives must stay together but also communicate information across the group. The cadherin superfamily of proteins mediates junctional adhesions between cells, but also serve many essential functions in collective cell migration. Besides keeping migrating cell collectives cohesive, cadherins help follower cells maintain their attachment to leader cells, transfer information about front-rear polarity among the cohort, sense and respond to changes in the tissue environment, and promote intracellular signaling, in addition to other cellular behaviors. In this review, we highlight recent studies that reveal diverse but critical roles for both classical and atypical cadherins in collective cell migration, specifically focusing on four in vivo model systems in development: the Drosophila border cells, zebrafish mesendodermal cells, Drosophila follicle rotation, and Xenopus neural crest cells." @default.
- W4382631336 created "2023-07-01" @default.
- W4382631336 creator A5003828770 @default.
- W4382631336 creator A5005880450 @default.
- W4382631336 date "2023-06-30" @default.
- W4382631336 modified "2023-10-17" @default.
- W4382631336 title "Expect the unexpected: conventional and unconventional roles for cadherins in collective cell migration" @default.
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- W4382631336 doi "https://doi.org/10.1042/bst20221202" @default.
- W4382631336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37387360" @default.
- W4382631336 hasPublicationYear "2023" @default.
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