Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382632016> ?p ?o ?g. }
- W4382632016 abstract "CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important roles in immunity and cancer. Complete CYLD ablation, truncation and expression of alternate isoforms, including short CYLD, drive distinct phenotypes and offer insights into CYLD function in inflammation, cell death, cell cycle progression and cell transformation. Research in diverse model systems has shown that these are mediated via CYLD regulation of cellular pathways including the NF-κB, Wnt and TGF-β pathways. Recent biochemical advances and models have offered new insights into the regulation and function of CYLD. In addition, recent discoveries of gain-of-function germline pathogenic CYLD variants in patients with a neurodegenerative phenotype contrast with the more widely known loss-of-function mutations seen in patients with CYLD cutaneous syndrome and with sporadic cancers. Here, we provide a current review of mechanistic insights into CYLD function gained from CYLD animal models, as well as an update on the role of CYLD in human disease." @default.
- W4382632016 created "2023-07-01" @default.
- W4382632016 creator A5020671002 @default.
- W4382632016 creator A5046278904 @default.
- W4382632016 creator A5062338155 @default.
- W4382632016 creator A5062394919 @default.
- W4382632016 creator A5079662327 @default.
- W4382632016 date "2023-06-01" @default.
- W4382632016 modified "2023-10-02" @default.
- W4382632016 title "CYLD in health and disease" @default.
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