FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382632093> ?p ?o ?g. }

• W4382632093 endingPage "13" @default.
• W4382632093 startingPage "1" @default.
• W4382632093 abstract "The Death-associated protein kinase 1 (DAPK1) has emerged as a crucial player in the pathogenesis of degenerative diseases. As a serine/threonine kinase family member, DAPK1 regulates critical signaling pathways, such as apoptosis and autophagy. In this study, we comprehensively analyzed DAPK1 interactors and enriched molecular functions, biological processes, phenotypic expression, disease associations, and aging signatures to elucidate the molecular networks of DAPK1. Furthermore, we employed a structure-based virtual screening approach using the PubChem database, which enabled the identification of potential bioactive compounds capable of inhibiting DAPK1, including caspase inhibitors and synthetic analogs. Three selected compounds, CID24602687, CID8843795, and CID110869998, exhibited high docking affinity and selectivity towards DAPK1, which were further investigated using molecular dynamics simulations to understand their binding patterns. Our findings establish a connection between DAPK1 and retinal degenerative diseases and highlight the potential of these selected compounds for the development of novel therapeutic strategies. This study provides valuable insights into the molecular mechanisms underlying DAPK1-related diseases, and offers new opportunities for the discovery of effective treatments for retinal degeneration.Communicated by Ramaswamy H. Sarma." @default.
• W4382632093 created "2023-07-01" @default.
• W4382632093 creator A5032018272 @default.
• W4382632093 creator A5075816568 @default.
• W4382632093 date "2023-06-30" @default.
• W4382632093 modified "2023-09-26" @default.
• W4382632093 title "Role of death-associated protein kinase 1 (DAPK1) in retinal degenerative diseases: an <i>in-silico</i> approach towards therapeutic intervention" @default.
• W4382632093 cites W1988410112 @default.
• W4382632093 cites W2017338994 @default.
• W4382632093 cites W2029667189 @default.
• W4382632093 cites W2040322845 @default.
• W4382632093 cites W2043740523 @default.
• W4382632093 cites W2053599146 @default.
• W4382632093 cites W2064463813 @default.
• W4382632093 cites W2076229436 @default.
• W4382632093 cites W2078916806 @default.
• W4382632093 cites W2102648626 @default.
• W4382632093 cites W2105668062 @default.
• W4382632093 cites W2119637652 @default.
• W4382632093 cites W2123131667 @default.
• W4382632093 cites W2130541969 @default.
• W4382632093 cites W2143445671 @default.
• W4382632093 cites W2150981663 @default.
• W4382632093 cites W2159675211 @default.
• W4382632093 cites W2162770915 @default.
• W4382632093 cites W2169678694 @default.
• W4382632093 cites W2206954826 @default.
• W4382632093 cites W2336040088 @default.
• W4382632093 cites W2345356016 @default.
• W4382632093 cites W2464666781 @default.
• W4382632093 cites W2585898252 @default.
• W4382632093 cites W2593436234 @default.
• W4382632093 cites W2749870290 @default.
• W4382632093 cites W2765930655 @default.
• W4382632093 cites W2796511578 @default.
• W4382632093 cites W2801088198 @default.
• W4382632093 cites W2809058317 @default.
• W4382632093 cites W2890113953 @default.
• W4382632093 cites W2898877713 @default.
• W4382632093 cites W2953067954 @default.
• W4382632093 cites W3004714792 @default.
• W4382632093 cites W3004817371 @default.
• W4382632093 cites W3047882216 @default.
• W4382632093 cites W3087671762 @default.
• W4382632093 cites W3110648523 @default.
• W4382632093 cites W3118988966 @default.
• W4382632093 cites W3162684419 @default.
• W4382632093 cites W3164839189 @default.
• W4382632093 cites W3174450391 @default.
• W4382632093 cites W4200285320 @default.
• W4382632093 cites W4212778254 @default.
• W4382632093 cites W4213420715 @default.
• W4382632093 cites W4221082514 @default.
• W4382632093 cites W4223945173 @default.
• W4382632093 cites W4224218448 @default.
• W4382632093 cites W4229378265 @default.
• W4382632093 cites W4255677297 @default.
• W4382632093 cites W4293207190 @default.
• W4382632093 cites W4296312466 @default.
• W4382632093 cites W4311114246 @default.
• W4382632093 cites W4313237407 @default.
• W4382632093 cites W4313594841 @default.
• W4382632093 cites W4318459933 @default.
• W4382632093 doi "https://doi.org/10.1080/07391102.2023.2227720" @default.
• W4382632093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37387600" @default.
• W4382632093 hasPublicationYear "2023" @default.
• W4382632093 type Work @default.
• W4382632093 citedByCount "1" @default.
• W4382632093 countsByYear W43826320932023 @default.
• W4382632093 crossrefType "journal-article" @default.
• W4382632093 hasAuthorship W4382632093A5032018272 @default.
• W4382632093 hasAuthorship W4382632093A5075816568 @default.
• W4382632093 hasConcept C104317684 @default.
• W4382632093 hasConcept C159110408 @default.
• W4382632093 hasConcept C184235292 @default.
• W4382632093 hasConcept C2775905019 @default.
• W4382632093 hasConcept C41685203 @default.
• W4382632093 hasConcept C55493867 @default.
• W4382632093 hasConcept C62478195 @default.
• W4382632093 hasConcept C70721500 @default.
• W4382632093 hasConcept C71924100 @default.
• W4382632093 hasConcept C86803240 @default.
• W4382632093 hasConcept C95444343 @default.
• W4382632093 hasConcept C97029542 @default.
• W4382632093 hasConceptScore W4382632093C104317684 @default.
• W4382632093 hasConceptScore W4382632093C159110408 @default.
• W4382632093 hasConceptScore W4382632093C184235292 @default.
• W4382632093 hasConceptScore W4382632093C2775905019 @default.
• W4382632093 hasConceptScore W4382632093C41685203 @default.
• W4382632093 hasConceptScore W4382632093C55493867 @default.
• W4382632093 hasConceptScore W4382632093C62478195 @default.
• W4382632093 hasConceptScore W4382632093C70721500 @default.
• W4382632093 hasConceptScore W4382632093C71924100 @default.
• W4382632093 hasConceptScore W4382632093C86803240 @default.
• W4382632093 hasConceptScore W4382632093C95444343 @default.
• W4382632093 hasConceptScore W4382632093C97029542 @default.
• W4382632093 hasFunder F4320334771 @default.
• W4382632093 hasLocation W43826320931 @default.

• next