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- W4382645979 abstract "Abusive head trauma in infants is a consequence of multiple episodes of abuse and results in axonal injury, brain atrophy, and chronic cognitive deficits. Anesthetized 11-day-old rats, neurologically equivalent to infants, were subjected to 1 impact/day to the intact skull for 3 successive days. Repeated, but not single impact(s) resulted in spatial learning deficits (p < 0.05 compared to sham-injured animals) up to 5 weeks postinjury. In the first week following single or repetitive brain injury, axonal and neuronal degeneration, and microglial activation were observed in the cortex, white matter, thalamus, and subiculum; the extent of the histopathologic damage was significantly greater in the repetitive-injured animals compared to single-injured animals. At 40 days postinjury, loss of cortical, white matter and hippocampal tissue was evident only in the repetitive-injured animals, along with evidence of microglial activation in the white matter tracts and thalamus. Axonal injury and neurodegeneration were evident in the thalamus up to 40 days postinjury in the repetitive-injured rats. These data demonstrate that while single closed head injury in the neonate rat is associated with pathologic alterations in the acute post-traumatic period, repetitive closed head injury results in sustained behavioral and pathologic deficits reminiscent of infants with abusive head trauma." @default.
- W4382645979 created "2023-07-01" @default.
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- W4382645979 date "2023-07-20" @default.
- W4382645979 modified "2023-10-05" @default.
- W4382645979 title "Repeated mild closed head injury in neonatal rats results in sustained cognitive deficits associated with chronic microglial activation and neurodegeneration" @default.
- W4382645979 cites W1559605882 @default.
- W4382645979 cites W1964467441 @default.
- W4382645979 cites W1968908485 @default.
- W4382645979 cites W1969196746 @default.
- W4382645979 cites W1976244656 @default.
- W4382645979 cites W1976758546 @default.
- W4382645979 cites W1977066638 @default.
- W4382645979 cites W1977687604 @default.
- W4382645979 cites W1978233152 @default.
- W4382645979 cites W1979510957 @default.
- W4382645979 cites W1979593135 @default.
- W4382645979 cites W1981248686 @default.
- W4382645979 cites W1981753157 @default.
- W4382645979 cites W1985035247 @default.
- W4382645979 cites W1985786338 @default.
- W4382645979 cites W1990339002 @default.
- W4382645979 cites W1991182430 @default.
- W4382645979 cites W1994915568 @default.
- W4382645979 cites W1996024251 @default.
- W4382645979 cites W1996421030 @default.
- W4382645979 cites W2001478447 @default.
- W4382645979 cites W2001689896 @default.
- W4382645979 cites W2002869490 @default.
- W4382645979 cites W2003674452 @default.
- W4382645979 cites W2003923114 @default.
- W4382645979 cites W2004943875 @default.
- W4382645979 cites W2005111601 @default.
- W4382645979 cites W2008005880 @default.
- W4382645979 cites W2009247821 @default.
- W4382645979 cites W2011033141 @default.
- W4382645979 cites W2012170786 @default.
- W4382645979 cites W2014634195 @default.
- W4382645979 cites W2019544787 @default.
- W4382645979 cites W2020408289 @default.
- W4382645979 cites W2023053581 @default.
- W4382645979 cites W2024324731 @default.
- W4382645979 cites W2024477313 @default.
- W4382645979 cites W2030688762 @default.
- W4382645979 cites W2033966441 @default.
- W4382645979 cites W2039242833 @default.
- W4382645979 cites W2042147373 @default.
- W4382645979 cites W2042512851 @default.
- W4382645979 cites W2043874843 @default.
- W4382645979 cites W2053937389 @default.
- W4382645979 cites W2058554387 @default.
- W4382645979 cites W2059467874 @default.
- W4382645979 cites W2068767931 @default.
- W4382645979 cites W2075906184 @default.
- W4382645979 cites W2077351028 @default.
- W4382645979 cites W2080717874 @default.
- W4382645979 cites W2081957132 @default.
- W4382645979 cites W2082429191 @default.
- W4382645979 cites W2083952664 @default.
- W4382645979 cites W2087113551 @default.
- W4382645979 cites W2089101596 @default.
- W4382645979 cites W2093259250 @default.
- W4382645979 cites W2094660330 @default.
- W4382645979 cites W2106851652 @default.
- W4382645979 cites W2107625098 @default.
- W4382645979 cites W2109759840 @default.
- W4382645979 cites W2112880160 @default.
- W4382645979 cites W2114562865 @default.
- W4382645979 cites W2118882984 @default.
- W4382645979 cites W2124228927 @default.
- W4382645979 cites W2126955333 @default.
- W4382645979 cites W2131231262 @default.
- W4382645979 cites W2137968618 @default.
- W4382645979 cites W2143601992 @default.
- W4382645979 cites W2145178512 @default.
- W4382645979 cites W2145179602 @default.
- W4382645979 cites W2146336136 @default.
- W4382645979 cites W2152521615 @default.
- W4382645979 cites W2158464373 @default.
- W4382645979 cites W2160477626 @default.
- W4382645979 cites W2166150070 @default.
- W4382645979 cites W2185982181 @default.
- W4382645979 cites W2305460710 @default.
- W4382645979 cites W2319887059 @default.
- W4382645979 cites W2324186508 @default.
- W4382645979 cites W2565920201 @default.
- W4382645979 cites W2761242880 @default.
- W4382645979 cites W2899571097 @default.
- W4382645979 cites W2939809860 @default.
- W4382645979 cites W4213135850 @default.
- W4382645979 cites W4322738842 @default.
- W4382645979 doi "https://doi.org/10.1093/jnen/nlad048" @default.
- W4382645979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37390808" @default.
- W4382645979 hasPublicationYear "2023" @default.
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