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• W4382652907 startingPage "65" @default.
• W4382652907 abstract "Noncoding RNAs (ncRNAs) are known to incorporate important monitoring roles in a plethora of different and intricate regulatory pathways. They act mostly at the posttranscriptional level, impeding gene expression. With the rapid improvements in sequencing technologies, numerous ncRNAs are reported and grouped, based on their transcript length, into long (lncRNA) and small ncRNAs (sncRNA). Here, we briefly describe the different types of ncRNAs, their biogenesis and mode of action, as well as different approaches to detecting and measuring ncRNAs. The importance of ncRNA in teleosts and, in particular, in miRNAs, which have been studied extensively, are discussed. Furthermore, P-element-induced wimpy testis (Piwi)-interacting RNA (piRNA) as well as lncRNAs are examined. We give an overview of ncRNA involvement in key processes in fish biology including development, reproduction, and immune response. The particularities of each of the processes are explained, starting from RNA extraction, via ncRNA library generation, to ncRNA annotation and target prediction. Examples are reported for the most-studied categories, like miRNAs, lncRNAs, and piRNAs. With the steady and rapid accumulation of ncRNA data, clear evidence of posttranscriptional regulation can be found. Nevertheless, accurate ncRNA annotation, detection, and characterization, as well as their mode of action remain complex. To date, ncRNAs present considerable potential for miRNA applications as biomarkers, as well as therapeutic targets for prevention and treatment." @default.
• W4382652907 created "2023-07-01" @default.
• W4382652907 creator A5001635342 @default.
• W4382652907 creator A5036546654 @default.
• W4382652907 date "2023-06-30" @default.
• W4382652907 modified "2023-09-25" @default.
• W4382652907 title "Epigenetic Regulation of Gene Expression by Noncoding RNAs" @default.
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