Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382654401> ?p ?o ?g. }
- W4382654401 abstract "Abstract We describe a genome editing strategy to reprogram the immunoglobulin heavy chain (IgH) locus of human B cells to express custom molecules that respond to immunization. These heavy chain antibodies (HCAbs) comprise a custom antigen-recognition domain linked to an Fc domain derived from the IgH locus and can be differentially spliced to express either B cell receptor (BCR) or secreted antibody isoforms. The HCAb editing platform is highly flexible, supporting antigen-binding domains based on both antibody and non-antibody components, and also allowing alterations in the Fc domain. Using HIV Env protein as a model antigen, we show that B cells edited to express anti-Env HCAbs support the regulated expression of both BCRs and antibodies, and respond to Env antigen in a tonsil organoid model of immunization. In this way, human B cells can be reprogrammed to produce customized therapeutic molecules with the potential for in vivo amplification." @default.
- W4382654401 created "2023-07-01" @default.
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- W4382654401 date "2023-06-30" @default.
- W4382654401 modified "2023-09-25" @default.
- W4382654401 title "Reprogramming human B cells with custom heavy chain antibodies" @default.
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- W4382654401 doi "https://doi.org/10.1101/2023.06.28.546944" @default.
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