Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382678675> ?p ?o ?g. }
- W4382678675 endingPage "104999" @default.
- W4382678675 startingPage "104999" @default.
- W4382678675 abstract "Hepatocytes on exposure to high levels of lipids reorganize the metabolic program while fighting against the toxicity associated with elevated cellular lipids. The mechanism of this metabolic reorientation and stress management in lipid-challenged hepatocytes has not been well explored. We have noted the lowering of miR-122, a liver-specific miRNA, in the liver of mice fed with either a high-fat diet or a methionine-choline-deficient diet that is associated with increased fat accumulation in mice liver. Interestingly, low miR-122 levels are attributed to the enhanced extracellular export of miRNA processor enzyme Dicer1 from hepatocytes in the presence of high lipids. Export of Dicer1 can also account for the increased cellular levels of pre-miR-122-the substrate of Dicer1. Interestingly, restoration of Dicer1 levels in the mouse liver resulted in a strong inflammatory response and cell death in the presence of high lipids. Increasing death of hepatocytes was found to be caused by increased miR-122 levels in hepatocytes restored for Dicer1. Thus, the Dicer1 export by hepatocytes seems to be a key mechanism to combat lipotoxic stress by shunting out miR-122 from stressed hepatocytes. Finally, as part of this stress management, we determined that the Ago2-interacting pool of Dicer1, responsible for mature microribonucleoprotein formation in mammalian cells, gets depleted. miRNA-binder and exporter protein HuR is found to accelerate Ago2-Dicer1 uncoupling to ensure export of Dicer1 via extracellular vesicles in lipid-loaded hepatocytes." @default.
- W4382678675 created "2023-07-01" @default.
- W4382678675 creator A5014001417 @default.
- W4382678675 creator A5023371410 @default.
- W4382678675 creator A5061520985 @default.
- W4382678675 creator A5061689047 @default.
- W4382678675 creator A5077690715 @default.
- W4382678675 creator A5088227251 @default.
- W4382678675 creator A5088290143 @default.
- W4382678675 date "2023-08-01" @default.
- W4382678675 modified "2023-10-14" @default.
- W4382678675 title "Accelerated export of Dicer1 from lipid-challenged hepatocytes buffers cellular miRNA-122 levels and prevents cell death" @default.
- W4382678675 cites W1141087116 @default.
- W4382678675 cites W1523155649 @default.
- W4382678675 cites W1545307027 @default.
- W4382678675 cites W1588774527 @default.
- W4382678675 cites W1648301895 @default.
- W4382678675 cites W1933173778 @default.
- W4382678675 cites W1974997620 @default.
- W4382678675 cites W1975437957 @default.
- W4382678675 cites W1980798766 @default.
- W4382678675 cites W1985175917 @default.
- W4382678675 cites W1992935306 @default.
- W4382678675 cites W1993589739 @default.
- W4382678675 cites W1997932830 @default.
- W4382678675 cites W2010965956 @default.
- W4382678675 cites W2015790286 @default.
- W4382678675 cites W2023162096 @default.
- W4382678675 cites W2027744584 @default.
- W4382678675 cites W2047256111 @default.
- W4382678675 cites W2048091871 @default.
- W4382678675 cites W2048858607 @default.
- W4382678675 cites W2058486562 @default.
- W4382678675 cites W2067082060 @default.
- W4382678675 cites W2067775919 @default.
- W4382678675 cites W2067943084 @default.
- W4382678675 cites W2070647652 @default.
- W4382678675 cites W2071097995 @default.
- W4382678675 cites W2071216600 @default.
- W4382678675 cites W2072841722 @default.
- W4382678675 cites W2086227770 @default.
- W4382678675 cites W2093805100 @default.
- W4382678675 cites W2096983987 @default.
- W4382678675 cites W2098422994 @default.
- W4382678675 cites W2107961632 @default.
- W4382678675 cites W2109057110 @default.
- W4382678675 cites W2109691647 @default.
- W4382678675 cites W2115271408 @default.
- W4382678675 cites W2117991391 @default.
- W4382678675 cites W2118258530 @default.
- W4382678675 cites W2119144998 @default.
- W4382678675 cites W2121570862 @default.
- W4382678675 cites W2135837360 @default.
- W4382678675 cites W2137130773 @default.
- W4382678675 cites W2140187466 @default.
- W4382678675 cites W2141138739 @default.
- W4382678675 cites W2146046635 @default.
- W4382678675 cites W2146512944 @default.
- W4382678675 cites W2149701793 @default.
- W4382678675 cites W2151912077 @default.
- W4382678675 cites W2154122744 @default.
- W4382678675 cites W2157253968 @default.
- W4382678675 cites W2162674813 @default.
- W4382678675 cites W2168006368 @default.
- W4382678675 cites W2270228161 @default.
- W4382678675 cites W2464549086 @default.
- W4382678675 cites W2492541041 @default.
- W4382678675 cites W2558650001 @default.
- W4382678675 cites W2592673836 @default.
- W4382678675 cites W2593099486 @default.
- W4382678675 cites W2617126712 @default.
- W4382678675 cites W2786514708 @default.
- W4382678675 cites W2903107073 @default.
- W4382678675 cites W3004240850 @default.
- W4382678675 cites W3005622563 @default.
- W4382678675 cites W3134111803 @default.
- W4382678675 cites W3145384825 @default.
- W4382678675 cites W3211864692 @default.
- W4382678675 cites W4211064852 @default.
- W4382678675 cites W4294216483 @default.
- W4382678675 doi "https://doi.org/10.1016/j.jbc.2023.104999" @default.
- W4382678675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37394005" @default.
- W4382678675 hasPublicationYear "2023" @default.
- W4382678675 type Work @default.
- W4382678675 citedByCount "0" @default.
- W4382678675 crossrefType "journal-article" @default.
- W4382678675 hasAuthorship W4382678675A5014001417 @default.
- W4382678675 hasAuthorship W4382678675A5023371410 @default.
- W4382678675 hasAuthorship W4382678675A5061520985 @default.
- W4382678675 hasAuthorship W4382678675A5061689047 @default.
- W4382678675 hasAuthorship W4382678675A5077690715 @default.
- W4382678675 hasAuthorship W4382678675A5088227251 @default.
- W4382678675 hasAuthorship W4382678675A5088290143 @default.
- W4382678675 hasBestOaLocation W43826786751 @default.
- W4382678675 hasConcept C104317684 @default.
- W4382678675 hasConcept C145059251 @default.
- W4382678675 hasConcept C1491633281 @default.
- W4382678675 hasConcept C185592680 @default.