Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382679040> ?p ?o ?g. }
- W4382679040 abstract "ABSTRACT The MAPK cascade plays a key role in transducing extracellular signals into cellular responses. As such, it is unsurprisingly hyperactive in various cancers, primarily due to activating or loss-of-function mutations of its components. Various pathologies, including cancer, are also characterized by deregulated protein synthesis, where imbalanced expression of eIFs is not only a consequence of neoplasia but itself a major contributor to it. eIF3 stands out as the largest, multi-subunit complex with a modular assembly, where aberrant expression of one subunit generates only partially functional subcomplexes. Here, we knocked-down eIF3d, eIF3e and eIF3h in HeLa cells and investigated their impact on differential gene expression by Ribo-Seq. Knock-downs of eIF3d and eIF3e activated the MAPK/ERK1/2 signaling despite reduced protein levels of its multiple components. Depletion of eIF3e and partially eIF3d also increased expression of ribosomal proteins, implicating eIF3 in controlling balanced production of mature ribosomes. Moreover, intact eIF3 also regulates the expression of the proto-oncogene MDM2 and the transcription factor ATF4, both containing short uORFs. eIF3 thus exerts specific translational control over signaling and stress-related transcripts." @default.
- W4382679040 created "2023-07-01" @default.
- W4382679040 creator A5018321975 @default.
- W4382679040 creator A5023570917 @default.
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- W4382679040 creator A5045087215 @default.
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- W4382679040 creator A5054995786 @default.
- W4382679040 creator A5061838104 @default.
- W4382679040 creator A5089273107 @default.
- W4382679040 date "2023-06-30" @default.
- W4382679040 modified "2023-09-30" @default.
- W4382679040 title "eIF3e and eIF3d control expression of riboproteins and key components of the MAPK signaling pathway" @default.
- W4382679040 cites W1560020441 @default.
- W4382679040 cites W1963688091 @default.
- W4382679040 cites W1969210187 @default.
- W4382679040 cites W1973290333 @default.
- W4382679040 cites W1974404622 @default.
- W4382679040 cites W1976367392 @default.
- W4382679040 cites W1987625491 @default.
- W4382679040 cites W1987928841 @default.
- W4382679040 cites W1988293105 @default.
- W4382679040 cites W1995352318 @default.
- W4382679040 cites W1995496043 @default.
- W4382679040 cites W2002038028 @default.
- W4382679040 cites W2004526658 @default.
- W4382679040 cites W2011892634 @default.
- W4382679040 cites W2020430280 @default.
- W4382679040 cites W2022371765 @default.
- W4382679040 cites W2022495797 @default.
- W4382679040 cites W2037313242 @default.
- W4382679040 cites W2037676225 @default.
- W4382679040 cites W2040885133 @default.
- W4382679040 cites W2045949302 @default.
- W4382679040 cites W2053304186 @default.
- W4382679040 cites W2056772716 @default.
- W4382679040 cites W2059127858 @default.
- W4382679040 cites W2062289724 @default.
- W4382679040 cites W2064073861 @default.
- W4382679040 cites W2066113694 @default.
- W4382679040 cites W2084952088 @default.
- W4382679040 cites W2086157203 @default.
- W4382679040 cites W2089716875 @default.
- W4382679040 cites W2097464861 @default.
- W4382679040 cites W2099257830 @default.
- W4382679040 cites W2103017472 @default.
- W4382679040 cites W2107368531 @default.
- W4382679040 cites W2111559515 @default.
- W4382679040 cites W2113028690 @default.
- W4382679040 cites W2117669008 @default.
- W4382679040 cites W2127848114 @default.
- W4382679040 cites W2129585918 @default.
- W4382679040 cites W2134526812 @default.
- W4382679040 cites W2134757689 @default.
- W4382679040 cites W2145828270 @default.
- W4382679040 cites W2157495054 @default.
- W4382679040 cites W2162228329 @default.
- W4382679040 cites W2165341580 @default.
- W4382679040 cites W2169456326 @default.
- W4382679040 cites W2170551349 @default.
- W4382679040 cites W2179438025 @default.
- W4382679040 cites W2223836536 @default.
- W4382679040 cites W2345356016 @default.
- W4382679040 cites W2485377503 @default.
- W4382679040 cites W2518959324 @default.
- W4382679040 cites W2534849249 @default.
- W4382679040 cites W2570763587 @default.
- W4382679040 cites W2581672374 @default.
- W4382679040 cites W2607484679 @default.
- W4382679040 cites W2621232571 @default.
- W4382679040 cites W2735527928 @default.
- W4382679040 cites W2739106951 @default.
- W4382679040 cites W2741666038 @default.
- W4382679040 cites W2755411663 @default.
- W4382679040 cites W2766224641 @default.
- W4382679040 cites W2770000599 @default.
- W4382679040 cites W2770320742 @default.
- W4382679040 cites W2775215876 @default.
- W4382679040 cites W2796317691 @default.
- W4382679040 cites W2800581234 @default.
- W4382679040 cites W2891029504 @default.
- W4382679040 cites W2899985953 @default.
- W4382679040 cites W2920879064 @default.
- W4382679040 cites W2928515356 @default.
- W4382679040 cites W2948030696 @default.
- W4382679040 cites W2969443468 @default.
- W4382679040 cites W2980897189 @default.
- W4382679040 cites W2981476691 @default.
- W4382679040 cites W2990079676 @default.
- W4382679040 cites W2996710494 @default.
- W4382679040 cites W2997022986 @default.
- W4382679040 cites W3014142178 @default.
- W4382679040 cites W3036759197 @default.
- W4382679040 cites W3037353559 @default.
- W4382679040 cites W3037736302 @default.
- W4382679040 cites W3037894722 @default.
- W4382679040 cites W3083393835 @default.
- W4382679040 cites W3089005554 @default.
- W4382679040 cites W3096568637 @default.