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• W4382680067 abstract "Oleanolic acid (OA), a common pentacyclic triterpenoid found in plants, has several therapeutic uses, including the treatment of hepatopathy disorders. However, due to OA’s weak permeability and limited bioavailability, its therapeutic advantages are limited. Here, we showed that a short peptide known as p10 not only binds to OA but also rapidly enhances OA delivery into cultured hepatic stellate cells (HSCs), lowers their synthesis of fibrogenic proteins, and further reduces the HSC migration capacity. Our findings show that noncovalently conjugating short peptides to OA improves its pharmacological efficacy and permeability." @default.
• W4382680067 created "2023-07-01" @default.
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• W4382680067 date "2023-06-30" @default.
• W4382680067 modified "2023-09-25" @default.
• W4382680067 title "Delivery of Oleanolic Acid with Improved Antifibrosis Efficacy by a Cell Penetrating Peptide P10" @default.
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• W4382680067 doi "https://doi.org/10.1021/acsptsci.3c00087" @default.
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