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- W4382700778 endingPage "115228" @default.
- W4382700778 startingPage "115228" @default.
- W4382700778 abstract "Pulmonary hypertension (PH) is complex disease as a result of obstructive pulmonary arterial remodeling, which in turn results in elevated pulmonary arterial pressure (PAP) and subsequent right ventricular heart failure, eventually leading to premature death. However, there is still a lack of a diagnostic blood-based biomarker and therapeutic target for PH. Because of the difficulty of diagnosis, new and more easily accessible prevention and treatment strategy are being explored. New target and diagnosis biomarkers should also allow for early diagnosis. In biology, miRNAs are short endogenous RNA molecules that are not coding. It is known that miRNAs can regulate gene expression and affect a variety of biological processes. Besides, miRNAs have been proven to be a crucial factor in PH pathogenesis. miRNAs have various effects on pulmonary vascular remodeling and are expressed differentially in various pulmonary vascular cells. Nowadays, it has been shown to be critical in the functions of different miRNAs in the pathogenesis of PH. Therefore, clarifying the mechanism of miRNAs regulating pulmonary vascular remodeling is of great importance to explore new therapeutic targets of PH and improve the survival qualify and time of patients. This review is focused on the role, mechanism, and potential therapeutic targets of miRNAs in PH and puts forward possible clinical treatment strategies." @default.
- W4382700778 created "2023-07-01" @default.
- W4382700778 creator A5005416373 @default.
- W4382700778 creator A5008749295 @default.
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- W4382700778 creator A5052304130 @default.
- W4382700778 creator A5077171356 @default.
- W4382700778 creator A5084527869 @default.
- W4382700778 date "2023-08-01" @default.
- W4382700778 modified "2023-10-12" @default.
- W4382700778 title "Critical miRNAs in regulating pulmonary hypertension: A focus on Signaling pathways and therapeutic Targets" @default.
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