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- W4382700878 abstract "CD27 is a member of the TNF-receptor superfamily and plays various roles in immunities. However, the detailed information and mechanism of CD27 in bony fish immunity remain unclear. Therefore, in this research, certain interesting roles of CD27 in Nile tilapia (On-CD27) were determined. On-CD27 was largely expressed in the immune organs, head kidney, and spleen, and was sharply induced during bacterial infection. The in vitro tests suggested On-CD27 was involved in regulating inflammatory responses, activating immune-related signal pathways, and inducing apoptosis and pyroptosis progress. The scRNA data and in vivo experiments indicated that On-CD27 is mainly expressed in CD4+ T cells and involved in both innate and adaptive immunities. The present data provide a theoretical principle for further research on the mechanisms of CD27 in the innate and adaptive immunities of fish." @default.
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- W4382700878 date "2023-08-01" @default.
- W4382700878 modified "2023-10-15" @default.
- W4382700878 title "Involvement of CD27 in innate and adaptive immunities of Nile tilapia (Oreochromis niloticus)" @default.
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- W4382700878 doi "https://doi.org/10.1016/j.fsi.2023.108923" @default.
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