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- W4382704645 endingPage "55" @default.
- W4382704645 startingPage "25" @default.
- W4382704645 abstract "HDAC6 and HDAC10 are class IIb HDAC isoenzymes. They have unique structural and physiological functions. They are key regulators of different physiological and pathological disease conditions. HDAC6 and HDAC10 are involved in different signaling pathways associated with several neurological disorders, various cancers at early as well as advanced stages, rare diseases, immunological conditions, etc. Thus, targeting these two enzymes has been found to be effective for various therapeutic purposes in recent years. More work is still needed to pinpoint the selectivity as well as potency of class IIb HDAC inhibitors (HDACi) for their clinical development. The present chapter deals with the structural biology of class IIb HDACs and discusses how in silico studies including the virtual screening approaches have been implemented to design HDAC6 and HDAC10 inhibitors. In addition, the interactions of class IIb HDACs with their inhibitors are also highlighted extensively to get a detail insight. This chapter offers understanding for designing newer class IIb HDAC inhibitors in future." @default.
- W4382704645 created "2023-07-01" @default.
- W4382704645 creator A5006932711 @default.
- W4382704645 creator A5036088778 @default.
- W4382704645 creator A5049584448 @default.
- W4382704645 creator A5072437390 @default.
- W4382704645 date "2023-01-01" @default.
- W4382704645 modified "2023-09-23" @default.
- W4382704645 title "In Silico Discovery of Class IIb HDAC Inhibitors: The State of Art" @default.
- W4382704645 cites W1487070667 @default.
- W4382704645 cites W1500036797 @default.
- W4382704645 cites W1542208531 @default.
- W4382704645 cites W1854810044 @default.
- W4382704645 cites W1923015860 @default.
- W4382704645 cites W1970651561 @default.
- W4382704645 cites W1974112332 @default.
- W4382704645 cites W1975692560 @default.
- W4382704645 cites W1992041755 @default.
- W4382704645 cites W1996507777 @default.
- W4382704645 cites W1998499089 @default.
- W4382704645 cites W2003189290 @default.
- W4382704645 cites W2005817231 @default.
- W4382704645 cites W2007996284 @default.
- W4382704645 cites W2008732224 @default.
- W4382704645 cites W2015669332 @default.
- W4382704645 cites W2021479491 @default.
- W4382704645 cites W2028265816 @default.
- W4382704645 cites W2030185116 @default.
- W4382704645 cites W2031110581 @default.
- W4382704645 cites W2038568403 @default.
- W4382704645 cites W2042315437 @default.
- W4382704645 cites W2046392396 @default.
- W4382704645 cites W2053174787 @default.
- W4382704645 cites W2054208176 @default.
- W4382704645 cites W2061360494 @default.
- W4382704645 cites W2063460322 @default.
- W4382704645 cites W2064959533 @default.
- W4382704645 cites W2070089404 @default.
- W4382704645 cites W2092151053 @default.
- W4382704645 cites W2101127235 @default.
- W4382704645 cites W2107733280 @default.
- W4382704645 cites W2108017291 @default.
- W4382704645 cites W2113056756 @default.
- W4382704645 cites W2116633922 @default.
- W4382704645 cites W2129635356 @default.
- W4382704645 cites W2132880072 @default.
- W4382704645 cites W2135830745 @default.
- W4382704645 cites W2146620343 @default.
- W4382704645 cites W2157830796 @default.
- W4382704645 cites W2320246267 @default.
- W4382704645 cites W2391153337 @default.
- W4382704645 cites W2475853404 @default.
- W4382704645 cites W2482664294 @default.
- W4382704645 cites W2515133122 @default.
- W4382704645 cites W2547560874 @default.
- W4382704645 cites W2588332509 @default.
- W4382704645 cites W2603468787 @default.
- W4382704645 cites W2613028861 @default.
- W4382704645 cites W2615685872 @default.
- W4382704645 cites W2745028397 @default.
- W4382704645 cites W2748954813 @default.
- W4382704645 cites W2766772940 @default.
- W4382704645 cites W2768629427 @default.
- W4382704645 cites W2772606519 @default.
- W4382704645 cites W2802581849 @default.
- W4382704645 cites W2805162488 @default.
- W4382704645 cites W2888790527 @default.
- W4382704645 cites W2891534559 @default.
- W4382704645 cites W2892157567 @default.
- W4382704645 cites W2902128418 @default.
- W4382704645 cites W2902417555 @default.
- W4382704645 cites W2909200248 @default.
- W4382704645 cites W2909768732 @default.
- W4382704645 cites W2912159735 @default.
- W4382704645 cites W2937262871 @default.
- W4382704645 cites W2951948509 @default.
- W4382704645 cites W2953849769 @default.
- W4382704645 cites W2955096901 @default.
- W4382704645 cites W2966630283 @default.
- W4382704645 cites W2968689781 @default.
- W4382704645 cites W2981198756 @default.
- W4382704645 cites W2988413354 @default.
- W4382704645 cites W2991486293 @default.
- W4382704645 cites W2994236371 @default.
- W4382704645 cites W2999915468 @default.
- W4382704645 cites W3006674793 @default.
- W4382704645 cites W3010683719 @default.
- W4382704645 cites W3010761615 @default.
- W4382704645 cites W3018429597 @default.
- W4382704645 cites W3023042104 @default.
- W4382704645 cites W3023126697 @default.
- W4382704645 cites W3034542176 @default.
- W4382704645 cites W3037826474 @default.
- W4382704645 cites W3043274348 @default.
- W4382704645 cites W3045235012 @default.
- W4382704645 cites W3087188501 @default.
- W4382704645 cites W3107093794 @default.
- W4382704645 cites W3119118882 @default.