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- W4382724583 abstract "Plateau potentials are a critical feature of neuronal excitability, but their all-or-none behavior is not easily captured in modeling. In this study, we investigated models of plateau potentials in multi-compartment neuron models and found that including glutamate spillover provides robust all-or-none behavior. This result arises due to the prolonged duration of extrasynaptic glutamate. When glutamate spillover is not included, the all-or-none behavior is very sensitive to the steepness of the Mg 2+ block. These results suggest a potentially significant role of glutamate spillover in plateau potential generation, providing a mechanism for robust all-or-none behavior across a wide range of slopes of the Mg 2+ block curve. We also illustrate the importance of the all-or-none plateau potential behavior for nonlinear computation with regard to the nonlinear feature binding problem." @default.
- W4382724583 created "2023-07-01" @default.
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- W4382724583 date "2023-06-29" @default.
- W4382724583 modified "2023-10-18" @default.
- W4382724583 title "Glutamate spillover drives robust all-or-none dendritic plateau potentials—an in silico investigation using models of striatal projection neurons" @default.
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- W4382724583 doi "https://doi.org/10.3389/fncel.2023.1196182" @default.
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