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• W4382724854 endingPage "7674" @default.
• W4382724854 startingPage "7674" @default.
• W4382724854 abstract "Unlike in many countries, in the USA, UV filters are treated as drugs and strictly regulated by the Food and Drug Administration. So far, 17 physical and chemical sunscreen agents were approved there to protect against the harmful effects of UV irradiation. In the European Union, access to UV filters is much larger, which gives manufacturers more options to create new sunscreen products in the form of lotions, sprays, oils, creams, gels, pastes, and sticks. Recently, concerns have been raised about the potential unfavorable effects of some UV filters that can penetrate the skin and enter into the systematic circulation. In this study, we prepared oil-in-water emulsions containing two commonly applied sunscreen agents, avobenzone and octyl methoxycinnamate. The formulations were characterized by a high stability at room temperature and a pH in the range of 6.02–6.11. The processes of sunscreen agent release and permeation were performed in a receptor fluid with a pH 5.8 using Strat-M and cellulose membranes to mimic the skin. It was proved that octyl methoxycinnamate exhibited different liberation and permeation patterns than avobenzone, mostly due to its higher lipophilicity. Both processes were also influenced by the type of membrane applied. The liberation of UV filters to the receptor fluid via the cellulose membrane depended on their concentration in the emulsion. As the amount of sunscreen agent in the formulation increases, more of its molecules diffuse to the receiving medium after 48 h. The permeation of the UV filters through the Strat-M membrane occurs at a very low level, 2% for octyl methoxycinnamate and 0.3% for avobenzone, which supports the safety and efficacy of the topical formulations obtained." @default.
• W4382724854 created "2023-07-01" @default.
• W4382724854 creator A5002505285 @default.
• W4382724854 creator A5018616995 @default.
• W4382724854 date "2023-06-28" @default.
• W4382724854 modified "2023-09-30" @default.
• W4382724854 title "Incorporation of UV Filters into Oil-in-Water Emulsions—Release and Permeability Characteristics" @default.
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• W4382724854 doi "https://doi.org/10.3390/app13137674" @default.
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