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- W4382725422 abstract "ABSTRACT Nanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography has been challenging due to the size and stability constraints of conventional bubble-based agents. Here we describe bicones, truly tiny acoustic contrast agents based on gas vesicles, a unique class of air-filled protein nanostructures naturally produced in buoyant microbes. We show that these sub-80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound-induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation." @default.
- W4382725422 created "2023-07-01" @default.
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- W4382725422 date "2023-06-28" @default.
- W4382725422 modified "2023-09-25" @default.
- W4382725422 title "Truly tiny acoustic biomolecules for ultrasound imaging and therapy" @default.
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- W4382725422 doi "https://doi.org/10.1101/2023.06.27.546773" @default.
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