Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382751570> ?p ?o ?g. }
- W4382751570 endingPage "10914" @default.
- W4382751570 startingPage "10914" @default.
- W4382751570 abstract "Resveratrol performs a variety of biological activities, including the potential regulation of autophagy. However, it is unclear whether resveratrol protects against luteal dysfunction and whether autophagy involves the regulation of resveratrol. This study aims to investigate whether resveratrol can regulate autophagy to resist H2O2-induced luteinized granulosa cell dysfunction in vitro. Our results showed that resveratrol can enhance cell viability, stimulate the secretion of progesterone and estradiol, and resist cell apoptosis in H2O2-induced luteinized granulosa cell dysfunction. Resveratrol can activate autophagy by stimulating the expression of autophagy-related genes at the transcriptional and translational levels and increasing the formation of autophagosomes and autophagolysosomes. Rapamycin, 3-methyladenine, and bafilomycin A1 regulated the levels of autophagy-related genes in H2O2-induced luteinized granulosa cell dysfunction and further confirmed the protective role of autophagy activated by resveratrol. In conclusion, resveratrol activates autophagy to resist H2O2-induced oxidative dysfunction, which is crucial for stabilizing the secretory function of luteinized granulosa cells and inhibiting apoptosis. This study may contribute to revealing the protective effects of resveratrol on resisting luteal dysfunction from the perspective of regulating autophagy." @default.
- W4382751570 created "2023-07-01" @default.
- W4382751570 creator A5008292444 @default.
- W4382751570 creator A5009702886 @default.
- W4382751570 creator A5017171605 @default.
- W4382751570 creator A5021876114 @default.
- W4382751570 creator A5031572694 @default.
- W4382751570 creator A5043448646 @default.
- W4382751570 creator A5055071879 @default.
- W4382751570 date "2023-06-30" @default.
- W4382751570 modified "2023-09-25" @default.
- W4382751570 title "Resveratrol Protects Rat Ovarian Luteinized Granulosa Cells from H2O2-Induced Dysfunction by Activating Autophagy" @default.
- W4382751570 cites W2083499498 @default.
- W4382751570 cites W2088671298 @default.
- W4382751570 cites W2099215275 @default.
- W4382751570 cites W2107277218 @default.
- W4382751570 cites W2108230430 @default.
- W4382751570 cites W2149572123 @default.
- W4382751570 cites W2192080449 @default.
- W4382751570 cites W2508534437 @default.
- W4382751570 cites W2550497802 @default.
- W4382751570 cites W2556696389 @default.
- W4382751570 cites W2604961095 @default.
- W4382751570 cites W2774358332 @default.
- W4382751570 cites W2789820715 @default.
- W4382751570 cites W2802792321 @default.
- W4382751570 cites W2809459372 @default.
- W4382751570 cites W2810037075 @default.
- W4382751570 cites W2900968153 @default.
- W4382751570 cites W2906158772 @default.
- W4382751570 cites W2909477364 @default.
- W4382751570 cites W2920775222 @default.
- W4382751570 cites W2947610223 @default.
- W4382751570 cites W2981121039 @default.
- W4382751570 cites W2990912547 @default.
- W4382751570 cites W2993309042 @default.
- W4382751570 cites W3000726246 @default.
- W4382751570 cites W3005857648 @default.
- W4382751570 cites W3009545006 @default.
- W4382751570 cites W3010716147 @default.
- W4382751570 cites W3011565224 @default.
- W4382751570 cites W3013352992 @default.
- W4382751570 cites W3022708010 @default.
- W4382751570 cites W3042374322 @default.
- W4382751570 cites W3043477355 @default.
- W4382751570 cites W3080341297 @default.
- W4382751570 cites W3084349540 @default.
- W4382751570 cites W3091390800 @default.
- W4382751570 cites W3092151554 @default.
- W4382751570 cites W3092666067 @default.
- W4382751570 cites W3094722331 @default.
- W4382751570 cites W3111099337 @default.
- W4382751570 cites W3114087646 @default.
- W4382751570 cites W3117252339 @default.
- W4382751570 cites W3122120786 @default.
- W4382751570 cites W3137439508 @default.
- W4382751570 cites W3148719272 @default.
- W4382751570 cites W3152454072 @default.
- W4382751570 cites W3159605245 @default.
- W4382751570 cites W3164112942 @default.
- W4382751570 cites W3164412707 @default.
- W4382751570 cites W3169239182 @default.
- W4382751570 cites W3173957025 @default.
- W4382751570 cites W3174383546 @default.
- W4382751570 cites W3180104497 @default.
- W4382751570 cites W3184762547 @default.
- W4382751570 cites W3200794610 @default.
- W4382751570 cites W3204183830 @default.
- W4382751570 cites W4200548388 @default.
- W4382751570 cites W4206380528 @default.
- W4382751570 cites W4281618300 @default.
- W4382751570 cites W4294084369 @default.
- W4382751570 cites W4307242021 @default.
- W4382751570 cites W4316673639 @default.
- W4382751570 cites W4362523758 @default.
- W4382751570 doi "https://doi.org/10.3390/ijms241310914" @default.
- W4382751570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37446088" @default.
- W4382751570 hasPublicationYear "2023" @default.
- W4382751570 type Work @default.
- W4382751570 citedByCount "0" @default.
- W4382751570 crossrefType "journal-article" @default.
- W4382751570 hasAuthorship W4382751570A5008292444 @default.
- W4382751570 hasAuthorship W4382751570A5009702886 @default.
- W4382751570 hasAuthorship W4382751570A5017171605 @default.
- W4382751570 hasAuthorship W4382751570A5021876114 @default.
- W4382751570 hasAuthorship W4382751570A5031572694 @default.
- W4382751570 hasAuthorship W4382751570A5043448646 @default.
- W4382751570 hasAuthorship W4382751570A5055071879 @default.
- W4382751570 hasBestOaLocation W43827515701 @default.
- W4382751570 hasConcept C134018914 @default.
- W4382751570 hasConcept C185592680 @default.
- W4382751570 hasConcept C190283241 @default.
- W4382751570 hasConcept C203522944 @default.
- W4382751570 hasConcept C2776816829 @default.
- W4382751570 hasConcept C2777203538 @default.
- W4382751570 hasConcept C2778324911 @default.
- W4382751570 hasConcept C53227056 @default.
- W4382751570 hasConcept C55493867 @default.