Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382765634> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4382765634 abstract "In recent years, real-world external controls (ECs) have grown in popularity as a tool to empower randomized placebo-controlled trials (RPCTs), particularly in rare diseases or cases where balanced randomization is unethical or impractical. However, as ECs are not always comparable to the RPCTs, direct borrowing ECs without scrutiny may heavily bias the treatment effect estimator. Our paper proposes a data-adaptive integrative framework capable of preventing unknown biases of ECs. The adaptive nature is achieved by dynamically sorting out a set of comparable ECs via bias penalization. Our proposed method can simultaneously achieve (a) the semiparametric efficiency bound when the ECs are comparable and (b) selective borrowing that mitigates the impact of the existence of incomparable ECs. Furthermore, we establish statistical guarantees, including consistency, asymptotic distribution, and inference, providing type-I error control and good power. Extensive simulations and two real-data applications show that the proposed method leads to improved performance over the RPCT-only estimator across various bias-generating scenarios." @default.
- W4382765634 created "2023-07-01" @default.
- W4382765634 creator A5001699296 @default.
- W4382765634 creator A5033916270 @default.
- W4382765634 creator A5035716528 @default.
- W4382765634 creator A5043454832 @default.
- W4382765634 creator A5070178181 @default.
- W4382765634 creator A5070203419 @default.
- W4382765634 date "2023-06-28" @default.
- W4382765634 modified "2023-09-25" @default.
- W4382765634 title "Integrating Randomized Placebo-Controlled Trial Data with External Controls: A Semiparametric Approach with Selective Borrowing" @default.
- W4382765634 doi "https://doi.org/10.48550/arxiv.2306.16642" @default.
- W4382765634 hasPublicationYear "2023" @default.
- W4382765634 type Work @default.
- W4382765634 citedByCount "0" @default.
- W4382765634 crossrefType "posted-content" @default.
- W4382765634 hasAuthorship W4382765634A5001699296 @default.
- W4382765634 hasAuthorship W4382765634A5033916270 @default.
- W4382765634 hasAuthorship W4382765634A5035716528 @default.
- W4382765634 hasAuthorship W4382765634A5043454832 @default.
- W4382765634 hasAuthorship W4382765634A5070178181 @default.
- W4382765634 hasAuthorship W4382765634A5070203419 @default.
- W4382765634 hasBestOaLocation W43827656341 @default.
- W4382765634 hasConcept C105795698 @default.
- W4382765634 hasConcept C111696304 @default.
- W4382765634 hasConcept C11413529 @default.
- W4382765634 hasConcept C126322002 @default.
- W4382765634 hasConcept C149782125 @default.
- W4382765634 hasConcept C154945302 @default.
- W4382765634 hasConcept C168563851 @default.
- W4382765634 hasConcept C185429906 @default.
- W4382765634 hasConcept C204243189 @default.
- W4382765634 hasConcept C2776214188 @default.
- W4382765634 hasConcept C2776436953 @default.
- W4382765634 hasConcept C33923547 @default.
- W4382765634 hasConcept C41008148 @default.
- W4382765634 hasConcept C71924100 @default.
- W4382765634 hasConceptScore W4382765634C105795698 @default.
- W4382765634 hasConceptScore W4382765634C111696304 @default.
- W4382765634 hasConceptScore W4382765634C11413529 @default.
- W4382765634 hasConceptScore W4382765634C126322002 @default.
- W4382765634 hasConceptScore W4382765634C149782125 @default.
- W4382765634 hasConceptScore W4382765634C154945302 @default.
- W4382765634 hasConceptScore W4382765634C168563851 @default.
- W4382765634 hasConceptScore W4382765634C185429906 @default.
- W4382765634 hasConceptScore W4382765634C204243189 @default.
- W4382765634 hasConceptScore W4382765634C2776214188 @default.
- W4382765634 hasConceptScore W4382765634C2776436953 @default.
- W4382765634 hasConceptScore W4382765634C33923547 @default.
- W4382765634 hasConceptScore W4382765634C41008148 @default.
- W4382765634 hasConceptScore W4382765634C71924100 @default.
- W4382765634 hasLocation W43827656341 @default.
- W4382765634 hasOpenAccess W4382765634 @default.
- W4382765634 hasPrimaryLocation W43827656341 @default.
- W4382765634 hasRelatedWork W1660493506 @default.
- W4382765634 hasRelatedWork W1987620537 @default.
- W4382765634 hasRelatedWork W2883711290 @default.
- W4382765634 hasRelatedWork W2949919985 @default.
- W4382765634 hasRelatedWork W2963621177 @default.
- W4382765634 hasRelatedWork W2994435929 @default.
- W4382765634 hasRelatedWork W3042241602 @default.
- W4382765634 hasRelatedWork W3125897357 @default.
- W4382765634 hasRelatedWork W3149538312 @default.
- W4382765634 hasRelatedWork W3123288520 @default.
- W4382765634 isParatext "false" @default.
- W4382765634 isRetracted "false" @default.
- W4382765634 workType "article" @default.