Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382775946> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4382775946 endingPage "6254" @default.
- W4382775946 startingPage "6246" @default.
- W4382775946 abstract "Merkel cell carcinoma (MCC) has a tendency for lymphatic spread and locoregional recurrence, although there is little data examining the risk factors for patients with lymph node-positive extremity lesions. The purpose of the current study was to examine the outcomes and risk factors associated with nodal metastasis in extremity MCC. We retrospectively reviewed the medical record of 120 patients with extremity MCC evaluated at our institution between 1994 and 2021. The mean age of this cohort was 71 years; 33% of patients were female; and 98% were Caucasian. Seventy-eight (65%) patients presented with localized disease. Thirty-seven (31%) patients had stage III disease, and five (4%) patients had stage IV disease. Treatment of primary lesions consisted primarily of margin-negative excision and adjuvant radiotherapy. Nodal metastases were most treated with adjuvant radiation or completion lymph node dissection. Five-year disease-specific survival in our series was 88% for patients with localized disease, 89% for stage IIIa disease, 40% for stage IIIb disease and 42% for stage IV. Factors associated with worse survival included immunosuppression and macroscopic nodal disease. In conclusion, extremity MCC has a low rate of local recurrence when treated with margin-negative excision and adjuvant radiation. However, treatment of nodal metastases remains a challenge with high rates of recurrence and mortality, particularly for patients who are immunosuppressed or who have macroscopic nodal disease." @default.
- W4382775946 created "2023-07-02" @default.
- W4382775946 creator A5011903248 @default.
- W4382775946 creator A5025488605 @default.
- W4382775946 creator A5061690851 @default.
- W4382775946 creator A5075218712 @default.
- W4382775946 creator A5079410266 @default.
- W4382775946 date "2023-06-30" @default.
- W4382775946 modified "2023-09-30" @default.
- W4382775946 title "Multidisciplinary Treatment of Merkel Cell Carcinoma of the Extremities: Outcomes and Factors Associated with Poor Survival in Nodal Disease" @default.
- W4382775946 cites W1979803486 @default.
- W4382775946 cites W1983594071 @default.
- W4382775946 cites W2066401368 @default.
- W4382775946 cites W2126020257 @default.
- W4382775946 cites W2132571078 @default.
- W4382775946 cites W2141924645 @default.
- W4382775946 cites W2312481109 @default.
- W4382775946 cites W2339890238 @default.
- W4382775946 cites W2765847865 @default.
- W4382775946 cites W2766362843 @default.
- W4382775946 cites W2896921428 @default.
- W4382775946 cites W2919153708 @default.
- W4382775946 cites W3005945929 @default.
- W4382775946 cites W3007959720 @default.
- W4382775946 cites W3080777812 @default.
- W4382775946 cites W3202583154 @default.
- W4382775946 cites W4200044570 @default.
- W4382775946 cites W4284975210 @default.
- W4382775946 cites W4361226222 @default.
- W4382775946 doi "https://doi.org/10.3390/curroncol30070462" @default.
- W4382775946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37504322" @default.
- W4382775946 hasPublicationYear "2023" @default.
- W4382775946 type Work @default.
- W4382775946 citedByCount "0" @default.
- W4382775946 crossrefType "journal-article" @default.
- W4382775946 hasAuthorship W4382775946A5011903248 @default.
- W4382775946 hasAuthorship W4382775946A5025488605 @default.
- W4382775946 hasAuthorship W4382775946A5061690851 @default.
- W4382775946 hasAuthorship W4382775946A5075218712 @default.
- W4382775946 hasAuthorship W4382775946A5079410266 @default.
- W4382775946 hasBestOaLocation W43827759461 @default.
- W4382775946 hasConcept C126322002 @default.
- W4382775946 hasConcept C141071460 @default.
- W4382775946 hasConcept C143998085 @default.
- W4382775946 hasConcept C146357865 @default.
- W4382775946 hasConcept C151730666 @default.
- W4382775946 hasConcept C2777546739 @default.
- W4382775946 hasConcept C2778342957 @default.
- W4382775946 hasConcept C2778804307 @default.
- W4382775946 hasConcept C2779134260 @default.
- W4382775946 hasConcept C2780849966 @default.
- W4382775946 hasConcept C3019992690 @default.
- W4382775946 hasConcept C509974204 @default.
- W4382775946 hasConcept C71924100 @default.
- W4382775946 hasConcept C72563966 @default.
- W4382775946 hasConcept C86803240 @default.
- W4382775946 hasConceptScore W4382775946C126322002 @default.
- W4382775946 hasConceptScore W4382775946C141071460 @default.
- W4382775946 hasConceptScore W4382775946C143998085 @default.
- W4382775946 hasConceptScore W4382775946C146357865 @default.
- W4382775946 hasConceptScore W4382775946C151730666 @default.
- W4382775946 hasConceptScore W4382775946C2777546739 @default.
- W4382775946 hasConceptScore W4382775946C2778342957 @default.
- W4382775946 hasConceptScore W4382775946C2778804307 @default.
- W4382775946 hasConceptScore W4382775946C2779134260 @default.
- W4382775946 hasConceptScore W4382775946C2780849966 @default.
- W4382775946 hasConceptScore W4382775946C3019992690 @default.
- W4382775946 hasConceptScore W4382775946C509974204 @default.
- W4382775946 hasConceptScore W4382775946C71924100 @default.
- W4382775946 hasConceptScore W4382775946C72563966 @default.
- W4382775946 hasConceptScore W4382775946C86803240 @default.
- W4382775946 hasIssue "7" @default.
- W4382775946 hasLocation W43827759461 @default.
- W4382775946 hasLocation W43827759462 @default.
- W4382775946 hasLocation W43827759463 @default.
- W4382775946 hasOpenAccess W4382775946 @default.
- W4382775946 hasPrimaryLocation W43827759461 @default.
- W4382775946 hasRelatedWork W1912171906 @default.
- W4382775946 hasRelatedWork W2003938723 @default.
- W4382775946 hasRelatedWork W2047967234 @default.
- W4382775946 hasRelatedWork W2118496982 @default.
- W4382775946 hasRelatedWork W2155941014 @default.
- W4382775946 hasRelatedWork W2163211346 @default.
- W4382775946 hasRelatedWork W2439875401 @default.
- W4382775946 hasRelatedWork W2792827604 @default.
- W4382775946 hasRelatedWork W4251270128 @default.
- W4382775946 hasRelatedWork W2525756941 @default.
- W4382775946 hasVolume "30" @default.
- W4382775946 isParatext "false" @default.
- W4382775946 isRetracted "false" @default.
- W4382775946 workType "article" @default.