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- W4382776010 endingPage "10866" @default.
- W4382776010 startingPage "10866" @default.
- W4382776010 abstract "Dry eye disease (DED) is a multifactorial ocular surface disorder arising from numerous interrelated underlying pathologies that trigger a self-perpetuating cycle of instability, hyperosmolarity, and ocular surface damage. Associated ocular discomfort and visual disturbance contribute negatively to quality of life. Ocular surface inflammation has been increasingly recognised as playing a key role in the pathophysiology of chronic DED. Current readily available anti-inflammatory agents successfully relieve symptoms, but often without addressing the underlying pathophysiological mechanism. The NOD-like receptor protein-3 (NLRP3) inflammasome pathway has recently been implicated as a key driver of ocular surface inflammation, as reported in pre-clinical and clinical studies of DED. This review discusses the intimate relationship between DED and inflammation, highlights the involvement of the inflammasome in the development of DED, describes existing anti-inflammatory therapies and their limitations, and evaluates the potential of the inflammasome in the context of the existing anti-inflammatory therapeutic landscape as a therapeutic target for effective treatment of the disease." @default.
- W4382776010 created "2023-07-02" @default.
- W4382776010 creator A5003040257 @default.
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- W4382776010 creator A5021747061 @default.
- W4382776010 creator A5045401080 @default.
- W4382776010 creator A5053566365 @default.
- W4382776010 date "2023-06-29" @default.
- W4382776010 modified "2023-10-02" @default.
- W4382776010 title "NLRP3 Inflammasome as a Potential Therapeutic Target in Dry Eye Disease" @default.
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