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- W4382776236 endingPage "10857" @default.
- W4382776236 startingPage "10857" @default.
- W4382776236 abstract "Tendinopathy, a prevalent overuse injury, lacks effective treatment options, leading to a significant impact on quality of life and socioeconomic burden. Mesenchymal stem/stromal cells (MSCs) and their secretome, including conditioned medium (CM) and extracellular vesicles (EVs), have shown promise in tissue regeneration and immunomodulation. However, it remains unclear which components of the secretome contribute to their therapeutic effects. This study aimed to compare the efficacy of CM, EVs, and the soluble protein fraction (PF) in treating inflamed tenocytes. CM exhibited the highest protein and particle concentrations, followed by PF and EVs. Inflammation significantly altered gene expression in tenocytes, with CM showing the most distinct separation from the inflamed control group. Treatment with CM resulted in the most significant differential gene expression, with both upregulated and downregulated genes related to inflammation and tissue regeneration. EV treatment also demonstrated a therapeutic effect, albeit to a lesser extent. These findings suggest that CM holds superior therapeutic efficacy compared with its EV fraction alone, emphasizing the importance of the complete secretome in tendon injury treatment." @default.
- W4382776236 created "2023-07-02" @default.
- W4382776236 creator A5008462269 @default.
- W4382776236 creator A5010712207 @default.
- W4382776236 creator A5014100755 @default.
- W4382776236 creator A5029468180 @default.
- W4382776236 creator A5036924482 @default.
- W4382776236 creator A5068178323 @default.
- W4382776236 date "2023-06-29" @default.
- W4382776236 modified "2023-09-27" @default.
- W4382776236 title "Mesenchymal Stem Cell Conditioned Medium Modulates Inflammation in Tenocytes: Complete Conditioned Medium Has Superior Therapeutic Efficacy than Its Extracellular Vesicle Fraction" @default.
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