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• W4382776247 abstract "Abstract Background and Aims Crohn’s disease [CD] and intestinal tuberculosis [ITB] are often difficult to differentiate. Mesenteric fat hypertrophy is a feature of CD. We evaluated the utility of fat indices (visceral fat [VF] and subcutaneous fat [SF]) in differentiating CD and ITB in children. Methods Symptomatic children diagnosed to have CD or ITB based on recommended criteria were enrolled. Clinical, anthropometric, and laboratory details were noted. Abdominal fat was measured on computed tomography in supine position at the level of L4 vertebrae. VF and SF area was measured separately by a radiologist, blinded to the diagnosis. The sum of VF and SF was taken as total fat [TF]. VF/SF and VF/TF ratios were calculated. Results Thirty-four (age 14 years [10.8–17.0], 14 boys) children were recruited: 12 had CD [seven boys, age 13.0 years] and 22 had ITB [seven boys, age 14.5 years]. VF area was higher in CD compared to ITB (18.34 cm2 [15.62–40.01] vs 6.48 cm2 [2.65–21.96]; p = 0.012). The SF and TF area was similar in ITB and CD. The ratios of VF/SF (0.82 [0.57–1.5] vs 0.33 [0.16–0.48]; p = 0.004) and VF/TF (0.45 [0.36–0.60] vs 0.25 [0.13–0.32]; p = 0.004) were significantly higher in CD. On comparing CD and ITB in boys and girls separately, the difference was significant for boys but not for girls. A VF/SF ratio of 0.609 predicted CD with a good sensitivity [75%] and specificity [86.4%] [area under the curve 0.795, 95% confidence interval 0.636–0.955; p = 0.005]. Conclusion The VF/SF ratio is a simple, non-invasive, objective parameter to differentiate CD and ITB in children, particularly boys. Larger studies are needed to validate this in girls." @default.
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• W4382776247 date "2023-07-20" @default.
• W4382776247 modified "2023-10-18" @default.
• W4382776247 title "Visceral Fat Indices: Do They Help Differentiate Crohn’s Disease and Intestinal Tuberculosis in Children?" @default.
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• W4382776247 doi "https://doi.org/10.1093/ecco-jcc/jjad109" @default.
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